Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 74559..75084 Replicon plasmid pSS2017-1
Accession NZ_CP053871
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SS2017

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag HPY00_RS24085 Protein ID WP_001159863.1
Coordinates 74559..74864 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag HPY00_RS24090 Protein ID WP_000813641.1
Coordinates 74866..75084 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY00_RS24050 69929..70489 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
HPY00_RS24055 71218..71703 - 486 WP_000905606.1 membrane protein -
HPY00_RS24060 71697..72206 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
HPY00_RS24065 72210..72923 - 714 Protein_82 EAL domain-containing protein -
HPY00_RS24070 72932..73714 - 783 WP_000082169.1 site-specific integrase -
HPY00_RS24075 73749..74270 - 522 WP_000198608.1 hypothetical protein -
HPY00_RS24080 74267..74557 - 291 WP_001266176.1 hypothetical protein -
HPY00_RS24085 74559..74864 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
HPY00_RS24090 74866..75084 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HPY00_RS24095 75760..76281 + 522 WP_010999942.1 hypothetical protein -
HPY00_RS24100 76765..77061 + 297 WP_001687482.1 hypothetical protein -
HPY00_RS24105 77555..78544 + 990 WP_001527061.1 RepB family plasmid replication initiator protein -
HPY00_RS24110 78803..79139 - 337 Protein_91 site-specific integrase -
HPY00_RS24115 79416..79797 - 382 Protein_92 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..95180 95180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T158206 WP_001159863.1 NZ_CP053871:c74864-74559 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T158206 NZ_CP069597:c981700-981395 [Dickeya dianthicola]
ATGCAATTCATTGTTTACCAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
ACCAAAGCGGCGTATGGTCATTCCGCTTATAGAATCGCATCACCTGTCTGAGAAGGTGAATAAAACGCTGTTCCCTCAGA
TCCGGATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTTCCCGTTGAAGTTATTGGTGAAGAGCTC
GCGGAGCTTGGCGACTATGCGGATGAGATCAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT158206 WP_000813641.1 NZ_CP053871:c75084-74866 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT158206 NZ_CP069597:c981921-981703 [Dickeya dianthicola]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAACTATCAGATTCTGAGTGCTGCCGGAGTCAATATTTCTGGTCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGCAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAAAATGGCTCGTTTGCTGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References