Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 73221..73746 Replicon plasmid pSL7202-1
Accession NZ_CP053866
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SL7207

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag HQ623_RS24045 Protein ID WP_001159863.1
Coordinates 73221..73526 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag HQ623_RS24050 Protein ID WP_000813641.1
Coordinates 73528..73746 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ623_RS24010 68591..69151 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
HQ623_RS24015 69880..70365 - 486 WP_000905606.1 membrane protein -
HQ623_RS24020 70359..70868 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
HQ623_RS24025 70872..71585 - 714 Protein_81 EAL domain-containing protein -
HQ623_RS24030 71594..72376 - 783 WP_000082169.1 site-specific integrase -
HQ623_RS24035 72411..72932 - 522 WP_000198608.1 hypothetical protein -
HQ623_RS24040 72929..73219 - 291 WP_001266176.1 hypothetical protein -
HQ623_RS24045 73221..73526 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
HQ623_RS24050 73528..73746 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HQ623_RS24055 74422..74943 + 522 WP_010999942.1 hypothetical protein -
HQ623_RS24060 75427..75723 + 297 WP_001687482.1 hypothetical protein -
HQ623_RS24065 76217..77206 + 990 WP_001527061.1 RepB family plasmid replication initiator protein -
HQ623_RS24070 77465..77801 - 337 Protein_90 site-specific integrase -
HQ623_RS24075 78078..78459 - 382 Protein_91 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93842 93842


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T158202 WP_001159863.1 NZ_CP053866:c73526-73221 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T158202 NZ_CP069596:c2266757-2266677 [Dickeya dianthicola]
AATGCCAACTTTTAGCGCACGGCTCTCTCCAAAGAGCCATTTCCCTAGACCGGGCACAGGAATCGTGTTCGGTCTTTTTT
T

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT158202 WP_000813641.1 NZ_CP053866:c73746-73528 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT158202 NZ_CP069596:2266675-2266757 [Dickeya dianthicola]
ATAAAAAAAGACCGAACACGATTCCTGTGCCCGGTCTAGGGAAATGGCTCTTTGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References