Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 68742..69652 Replicon plasmid unnamed1
Accession NZ_CP053863
Organism Klebsiella pneumoniae strain KP-Zhen

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag GWF98_RS26310 Protein ID WP_004026354.1
Coordinates 69182..69652 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag GWF98_RS26305 Protein ID WP_004026357.1
Coordinates 68742..69185 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWF98_RS26275 (GWF98_26265) 63760..64281 + 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -
GWF98_RS26280 (GWF98_26270) 64278..65231 + 954 Protein_71 fec operon regulator FecR -
GWF98_RS26285 (GWF98_26275) 65318..67444 + 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
GWF98_RS26290 (GWF98_26280) 67519..67638 + 120 Protein_73 Fe3+-citrate ABC transporter substrate-binding protein -
GWF98_RS26295 (GWF98_26285) 67819..68040 + 222 WP_004213643.1 DUF2188 domain-containing protein -
GWF98_RS26300 (GWF98_26290) 68138..68641 + 504 Protein_75 DUF4113 domain-containing protein -
GWF98_RS26305 (GWF98_26295) 68742..69185 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
GWF98_RS26310 (GWF98_26300) 69182..69652 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
GWF98_RS26315 (GWF98_26305) 69801..70498 + 698 WP_223175001.1 IS1-like element IS1A family transposase -
GWF98_RS26320 (GWF98_26310) 71884..72534 - 651 WP_068893702.1 DUF1173 family protein -
GWF98_RS26325 72567..72833 - 267 WP_223175074.1 DUF1173 family protein -
GWF98_RS26330 (GWF98_26315) 73011..73505 + 495 WP_004212794.1 thermonuclease family protein -
GWF98_RS26335 (GWF98_26320) 73842..74240 + 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / iroN / iroD / iroC / iroB 1..222711 222711
- flank IS/Tn - - 69995..70498 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T158199 WP_004026354.1 NZ_CP053863:69182-69652 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T158199 NZ_CP069596:1578334-1578648 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACTGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTAAATCGCCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGTAAAGAATACGCCGTAATGGCGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTCTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT158199 WP_004026357.1 NZ_CP053863:68742-69185 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT158199 NZ_CP069596:1578095-1578331 [Dickeya dianthicola]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGCTCCGGGCGCGTGAAGCGGG
TATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACCGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References