Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4867827..4868343 Replicon chromosome
Accession NZ_CP053862
Organism Klebsiella pneumoniae strain KP-Zhen

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag GWF98_RS23315 Protein ID WP_004178374.1
Coordinates 4867827..4868111 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GWF98_RS23320 Protein ID WP_002886901.1
Coordinates 4868101..4868343 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWF98_RS23290 (4863223) 4863223..4863486 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
GWF98_RS23295 (4863616) 4863616..4863789 + 174 WP_041169004.1 hypothetical protein -
GWF98_RS23300 (4863792) 4863792..4864535 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GWF98_RS23305 (4864892) 4864892..4867030 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
GWF98_RS23310 (4867359) 4867359..4867823 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GWF98_RS23315 (4867827) 4867827..4868111 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GWF98_RS23320 (4868101) 4868101..4868343 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GWF98_RS23325 (4868421) 4868421..4870331 - 1911 WP_012737231.1 PRD domain-containing protein -
GWF98_RS23330 (4870354) 4870354..4871508 - 1155 WP_012737230.1 lactonase family protein -
GWF98_RS23335 (4871575) 4871575..4872315 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T158196 WP_004178374.1 NZ_CP053862:c4868111-4867827 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T158196 NZ_CP069596:c988560-987904 [Dickeya dianthicola]
GTGGCCTATGACTACAGCGCCAATCTCAACCCGGAAAAGGCCCTTATCTGGCGCATTGTCCACCGGGACAACATCCCGTG
GATACTGGACAACGGTCTACACTGCGGCAACAGCCCGGTGCAGGCTGCAAACTGGATCAATATTGGTAACCCGGAGCTTA
TCAACAGACGCGCCGGGCACCCGGTGCCTGCCGGGGCGGGTGGTACGCTGCATGACTATGTGCCGTTTTACTTTACCCCC
TTCTCACCGATGCTGATGAATATCCACAGTGGGCGCGGCGGCATTAAGCAACGTCCCAACGAAGAAATCGTCATTCTGGT
CAGCAGCCTGCGACATGTGGCGATACAAAACGTCCCCTTCGTGTTTACCGACAGCCACGCCTACTATAATCTGGCGAATT
ACTATACCGATCTAAACAATCTGCACCGGATCGACTGGCCCATTTTACAGGCGCGGGATTTCCGTCGCGATCAGGACGAT
CTTGCCAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGCAGCACTGCCCCATCACGCTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAATGGCTGTCGCAACGCAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT158196 WP_002886901.1 NZ_CP053862:c4868343-4868101 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT158196 NZ_CP069596:c987907-986840 [Dickeya dianthicola]
ATGATGACATATACACAAGGCAATTTACTGGACGCGCCCGTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGATAATATGAAAGCCTATGCACTCGCCTGTAAACAAAAGC
AGGTGACGACTGGCAAAATGTTTATCACTGAAACCGACGAGCTGATGGGGCCACGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCTCGCATGGAGTGGATTGAAGACGGCTTACAGGACTTACGTCGCTTTTTGATCGAAGAGAA
AGTGCAGTCCATCGCCATTCCTCCGCTGGGGGCGGGAAACGGCGGCCTGAACTGGTCGGACGTGCAGGCGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATCCTGATTTATGAGCCTACCGAAAAATACCAAAACGTCGCCAAGAGTACC
GGCGTAAAAAAGCTCACCCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGCGCCATTGAACAGCACCAGCAGGAGGACGTGCTAAAACTGC
GGTTTGAGGCACACAATTATGGCCCGTATGCCCCCAACCTGAACCATCTGCTTAACGCGCTGGACGGCACCTATCTGAAG
GCCGAGAAACGCATCCCGGACAGCCAGCCGCTGGACGTGATCTGGTTTAACGATCGGGAAAAAGAACACATTAATCTCTG
GCTGAATAACGAGGCCAAAGCGTGGCTACCGGCGCTTGAGCAGGTCAGCCAGTTGATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGCTGCTGGCGACCGTTGACTGGCTGCTGACCCGAGGAGAGTGCCAGCCCACGCTGGATTCCGTGAAAGAGGGG
CTACACCAGTGGCCTGCCGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTCTTTGACGACAAAAATCTGCAATTTGCCAT
AAACCGTGTCATGGAGTTCCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References