Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4109210..4109829 Replicon chromosome
Accession NZ_CP053862
Organism Klebsiella pneumoniae strain KP-Zhen

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GWF98_RS19745 Protein ID WP_002892050.1
Coordinates 4109611..4109829 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GWF98_RS19740 Protein ID WP_002892066.1
Coordinates 4109210..4109584 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWF98_RS19730 (4104362) 4104362..4105555 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GWF98_RS19735 (4105578) 4105578..4108724 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GWF98_RS19740 (4109210) 4109210..4109584 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GWF98_RS19745 (4109611) 4109611..4109829 + 219 WP_002892050.1 HHA domain-containing protein Toxin
GWF98_RS19750 (4109988) 4109988..4110554 + 567 WP_002892030.1 maltose O-acetyltransferase -
GWF98_RS19755 (4110526) 4110526..4110666 - 141 WP_004147370.1 hypothetical protein -
GWF98_RS19760 (4110687) 4110687..4111157 + 471 WP_002892026.1 YlaC family protein -
GWF98_RS19765 (4111132) 4111132..4112583 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
GWF98_RS19770 (4112684) 4112684..4113382 + 699 WP_002892021.1 GNAT family protein -
GWF98_RS19775 (4113379) 4113379..4113519 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GWF98_RS19780 (4113519) 4113519..4113782 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T158194 WP_002892050.1 NZ_CP053862:4109611-4109829 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T158194 NZ_CP069596:733246-733677 [Dickeya dianthicola]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGCTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCGCCCTGGTCGGACGGCTATGCGCCGCTGTGGTTGGGCCTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGTTCGGCGCCCGTGGGTAATGCGCAACGGCGTGTTGCTGTCATTGCGGGCAACGAATGGCAAAGGGCA
TCAGCGCTTGTGGCTGGCGTCAGACAGTATGGGTAACGAAGAATGGCGGCTGTTGCGCCAACTGTTGCAGCAGCATCCGT
TGCAGGGAACCGAATCCTCCCGCCATCATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT158194 WP_002892066.1 NZ_CP053862:4109210-4109584 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT158194 NZ_CP069596:732999-733265 [Dickeya dianthicola]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAATATGACACGCTGAGCGACGACGACAAGCTGCACTTCATTCGTCTGCTGCAGTGCGATGATCCCGACT
TGTTCAACTGGCTGATGAATCATGGCGAGCCGGTAGATCCGGCGCTGAAACGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References