Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797729..798386 Replicon chromosome
Accession NZ_CP053862
Organism Klebsiella pneumoniae strain KP-Zhen

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GWF98_RS03960 Protein ID WP_002916310.1
Coordinates 797976..798386 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GWF98_RS03955 Protein ID WP_002916312.1
Coordinates 797729..797995 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWF98_RS03930 (792936) 792936..794369 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
GWF98_RS03935 (794488) 794488..795216 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
GWF98_RS03940 (795266) 795266..795577 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GWF98_RS03945 (795742) 795742..796401 + 660 WP_002916317.1 hemolysin III family protein -
GWF98_RS03950 (796500) 796500..797483 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
GWF98_RS03955 (797729) 797729..797995 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GWF98_RS03960 (797976) 797976..798386 + 411 WP_002916310.1 protein YgfX Toxin
GWF98_RS03965 (798393) 798393..798914 - 522 WP_002916308.1 flavodoxin FldB -
GWF98_RS03970 (799015) 799015..799911 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GWF98_RS03975 (799934) 799934..800647 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GWF98_RS03980 (800653) 800653..802386 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T158184 WP_002916310.1 NZ_CP053862:797976-798386 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T158184 NZ_CP069595:c981700-981395 [Dickeya dianthicola]
ATGCAATTCATTGTTTACCAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
ACCAAAGCGGCGTATGGTCATTCCGCTTATAGAATCGCATCACCTGTCTGAGAAGGTGAATAAAACGCTGTTCCCTCAGA
TCCGGATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTTCCCGTTGAAGTTATTGGTGAAGAGCTC
GCGGAGCTTGGCGACTATGCGGATGAGATCAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT158184 WP_002916312.1 NZ_CP053862:797729-797995 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT158184 NZ_CP069595:c981921-981703 [Dickeya dianthicola]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAACTATCAGATTCTGAGTGCTGCCGGAGTCAATATTTCTGGTCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGCAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAAAATGGCTCGTTTGCTGATGAAAACAGGAACTGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References