Detailed information of TA system TA158177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3628861..3629957
• Replicon: chromosome
• Accession: NZ_CP053855
• Organism: Escherichia coli strain 258E

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A8S7TJ53
• Locus tag: HPY99_RS17225
• Protein ID: WP_063112742.1
• Coordinates: 3629127..3629957 (+)
• Length: 277 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HPY99_RS17220
• Protein ID: WP_001296726.1
• Coordinates: 3628861..3629127 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY99_RS17220 (3628861)	3628861..3629127	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HPY99_RS17225 (3629127)	3629127..3629957	+	831	WP_063112742.1	HipA N-terminal domain-containing protein	Toxin
HPY99_RS17230 (3630269)	3630269..3630477	+	209	Protein_3360	AraC family transcriptional regulator	-
HPY99_RS17235 (3630909)	3630909..3631472	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
HPY99_RS17240 (3631832)	3631832..3632542	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	3628861..3644456	15595

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (115-237)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 277 a.a.
• Molecular weight: 31181.99 Da
• Isoelectric Point: 10.0235

>T158177 WP_063112742.1 NZ_CP053855:3629127-3629957 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGS
YRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALD
NVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 831 bp

>T158177 NZ_CP069594:369703-370014 [Pseudomonas sp. Y39-6]
GTGCTTCTCGTTAAATGGCGACCTGAGGCTATTGTCGCCCTGATCGAGATCATTGATTACATCGAGCAGTACAACCCGGT
TGCCGCCGTCTCGCTGCACCAAACTATTGTGGTTGCCGCCGAGGGGTTGTCCCTGATGCCATACGGATTCAAGCACGGTC
GCTTGTCTGGTACTCGGGAAATGGTTGTTCATCCAAACTACCTGGTGGTCTATCGGGTGACGGAGCACGTTGAGATAGTG
ATGGTGTTACACACTCGCCAGGAATATCCCAGGGATGTGATCGGGCCACACCACTCGACCTCACGCCAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT158177 WP_001296726.1 NZ_CP053855:3628861-3629127 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT158177 NZ_CP069594:369525-369716 [Pseudomonas sp. Y39-6]
ATGAGCATTCCACGTTCTCCCATCGTTTCGGAGTTTGAAACAGAAGAGCAAGCTGCCAGCTACGACCGTTGGTTTCGTGC
CAAGGTGCAGGCTTCAATTGACGATCCTCGTCCTAGTATTCCGCACGATCAGGCGATGGCTGAAGTCGAGAAGGTGCTGG
AAGAGAGGCGCAAGGCTCGTGCTTCTCGTTAA