158137

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 916290..917127 Replicon chromosome
Accession NZ_CP053852
Organism Escherichia coli strain CE1628

Toxin (Protein)


Gene name itaT Uniprot ID A0A1M0D5U3
Locus tag HPM96_RS04465 Protein ID WP_000227782.1
Coordinates 916290..916832 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID B1LJI1
Locus tag HPM96_RS04470 Protein ID WP_001353405.1
Coordinates 916816..917127 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPM96_RS04440 911368..911958 - 591 WP_001276320.1 protein deglycase YajL -
HPM96_RS04445 911921..912832 - 912 WP_000705841.1 2-dehydropantoate 2-reductase -
HPM96_RS04450 913000..913491 + 492 WP_001138904.1 nucleotide binding protein YajQ -
HPM96_RS04455 913619..914983 - 1365 WP_001000978.1 MFS transporter -
HPM96_RS04460 915390..916234 + 845 Protein_875 sel1 repeat family protein -
HPM96_RS04465 916290..916832 - 543 WP_000227782.1 GNAT family N-acetyltransferase Toxin
HPM96_RS04470 916816..917127 - 312 WP_001353405.1 DUF1778 domain-containing protein Antitoxin
HPM96_RS04475 917312..918202 - 891 WP_000971327.1 heme o synthase -
HPM96_RS04480 918214..918543 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
HPM96_RS04485 918543..919157 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
HPM96_RS04490 919147..921138 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
HPM96_RS04495 921160..922107 - 948 WP_001239437.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19957.31 Da        Isoelectric Point: 9.1763

>T158137 WP_000227782.1 NZ_CP053852:c916832-916290 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDIIYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCNFFEHVKIIHRALPIKGVYLDADPAAINFYTRLGFVQLSA
RPNVFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T158137 NZ_CP069583:c4253809-4253522 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11370.09 Da        Isoelectric Point: 10.4825

>AT158137 WP_001353405.1 NZ_CP053852:c917127-916816 [Escherichia coli]
MPGKTVALPDIDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT158137 NZ_CP069583:c4253535-4253233 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0D5U3

Antitoxin

Source ID Structure
AlphaFold DB A0A829G7G3

References