Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1321272..1321867 Replicon chromosome
Accession NZ_CP053851
Organism Escherichia coli strain CE1803A

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag HPM97_RS06225 Protein ID WP_000239581.1
Coordinates 1321272..1321622 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag HPM97_RS06230 Protein ID WP_001223213.1
Coordinates 1321616..1321867 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPM97_RS06205 1316726..1317748 - 1023 WP_001361374.1 ABC transporter permease -
HPM97_RS06210 1317762..1319264 - 1503 WP_001095661.1 sugar ABC transporter ATP-binding protein -
HPM97_RS06215 1319397..1320353 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HPM97_RS06220 1320663..1321193 + 531 WP_000055072.1 inorganic diphosphatase -
HPM97_RS06225 1321272..1321622 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
HPM97_RS06230 1321616..1321867 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HPM97_RS06235 1322079..1322420 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HPM97_RS06240 1322423..1326202 - 3780 WP_000060873.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T158112 WP_000239581.1 NZ_CP053851:c1321622-1321272 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T158112 NZ_CP069572:c30601-30395 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCTTTGCTGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGAG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT158112 WP_001223213.1 NZ_CP053851:c1321867-1321616 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT158112 NZ_CP069572:30588-30649 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References