Detailed information of TA system TA158106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 302857..303562
• Replicon: chromosome
• Accession: NZ_CP053851
• Organism: Escherichia coli strain CE1803A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1M2J6W7
• Locus tag: HPM97_RS01400
• Protein ID: WP_000539524.1
• Coordinates: 302857..303243 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPM97_RS01405
• Protein ID: WP_001280945.1
• Coordinates: 303233..303562 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPM97_RS01380	298861..299487	+	627	WP_001295292.1	glutathione S-transferase GstB	-
HPM97_RS01385	299484..300599	-	1116	WP_000555056.1	aldose sugar dehydrogenase YliI	-
HPM97_RS01390	300710..301093	-	384	WP_000497137.1	biofilm formation regulator BssR	-
HPM97_RS01395	301306..302631	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
HPM97_RS01400	302857..303243	+	387	WP_000539524.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPM97_RS01405	303233..303562	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
HPM97_RS01410	303632..304960	-	1329	WP_000086870.1	GGDEF domain-containing protein	-
HPM97_RS01415	304968..307316	-	2349	WP_000950331.1	EAL domain-containing protein	-
HPM97_RS01420	307493..308404	-	912	WP_001236044.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14321.46 Da
• Isoelectric Point: 9.9521

>T158106 WP_000539524.1 NZ_CP053851:302857-303243 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSRSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T158106 NZ_CP069571:c3502514-3502338 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT158106 WP_001280945.1 NZ_CP053851:303233-303562 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT158106 NZ_CP069571:c3502292-3501876 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A1M2J6W7