Detailed information of TA system TA158103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 1272423..1272988
• Replicon: chromosome
• Accession: NZ_CP053836
• Organism: Halarcobacter ebronensis strain LMG 27922

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: AEBR_RS06300
• Protein ID: WP_129087631.1
• Coordinates: 1272423..1272719 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: AEBR_RS06305
• Protein ID: WP_129087630.1
• Coordinates: 1272716..1272988 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AEBR_RS06280	1267447..1268430	+	984	WP_129087634.1	virulence RhuM family protein	-
AEBR_RS06285	1268441..1271500	+	3060	WP_129087633.1	type I restriction endonuclease subunit R	-
AEBR_RS06290	1271533..1271685	+	153	WP_164969501.1	hypothetical protein	-
AEBR_RS06295	1271657..1272277	+	621	WP_129087632.1	Fic family protein	-
AEBR_RS06300	1272423..1272719	+	297	WP_129087631.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AEBR_RS06305	1272716..1272988	+	273	WP_129087630.1	putative addiction module antidote protein	Antitoxin
AEBR_RS06310	1273114..1273785	+	672	WP_129087702.1	ThiF family adenylyltransferase	-
AEBR_RS06315	1273915..1277154	+	3240	WP_129087629.1	carbamoyl-phosphate synthase large subunit	-
AEBR_RS06320	1277154..1277597	+	444	WP_129087628.1	Sua5 YciO YrdC YwlC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-96)

Antitoxin

• Uncharacterized protein HI1420 (10-88)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11561.65 Da
• Isoelectric Point: 10.1588

>T158103 WP_129087631.1 NZ_CP053836:1272423-1272719 [Halarcobacter ebronensis]
MTYKIRETEYFSKWLYKLKDIKAKVAILRRIERMKNGNFGDHKSLCDELSELRFTLGAGYRVYYTIRDKEIIILLLGGDK
STQAKDIEKAIKVLKELK

Nucleotide

• Length: 297 bp

>T158103 NZ_CP069571:2143358-2143693 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9933.50 Da
• Isoelectric Point: 5.0941

>AT158103 WP_129087630.1 NZ_CP053836:1272716-1272988 [Halarcobacter ebronensis]
MIKDFDISNYLDSKEIIAEYLSQVLQDGDMDELLNAIGYIAKAKGMTEISKDTGLGRESLYKTFAKGSKPKFETVLKVLN
SLGIKLQAVA

Nucleotide

• Length: 273 bp

>AT158103 NZ_CP069571:2143110-2143358 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA