Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1328862..1329387 Replicon chromosome
Accession NZ_CP053835
Organism Arcobacter defluvii strain LMG 25694

Toxin (Protein)


Gene name relE Uniprot ID A0A0G9JVW9
Locus tag ADFLV_RS06740 Protein ID WP_046997415.1
Coordinates 1328862..1329146 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0G9JP98
Locus tag ADFLV_RS06745 Protein ID WP_014468874.1
Coordinates 1329136..1329387 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADFLV_RS06720 1324669..1325001 + 333 WP_164968555.1 CRISPR-associated endonuclease Cas2 -
ADFLV_RS06725 1327069..1327275 - 207 WP_129012215.1 hypothetical protein -
ADFLV_RS06730 1327289..1327885 - 597 WP_129012214.1 hypothetical protein -
ADFLV_RS06735 1328099..1328347 - 249 WP_129012213.1 hypothetical protein -
ADFLV_RS06740 1328862..1329146 - 285 WP_046997415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ADFLV_RS06745 1329136..1329387 - 252 WP_014468874.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ADFLV_RS06750 1330192..1330578 - 387 WP_129012212.1 hypothetical protein -
ADFLV_RS06755 1331097..1331267 + 171 WP_164968554.1 hypothetical protein -
ADFLV_RS06760 1331268..1331909 + 642 WP_129012211.1 GNAT family N-acetyltransferase -
ADFLV_RS06765 1331913..1332995 - 1083 WP_172658766.1 tyrosine-type recombinase/integrase -
ADFLV_RS06770 1333322..1334080 + 759 WP_129011549.1 flagellar motor stator protein MotA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1230091..1333181 103090


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11230.15 Da        Isoelectric Point: 10.1830

>T158102 WP_046997415.1 NZ_CP053835:c1329146-1328862 [Arcobacter defluvii]
MTYNLEFKPQALKEWTKLGSTIKEQFKKKLEERLENPKVEKDKLSGYENVYKIKLKTAGYRLAYQVKDEEIVVLVLSVGK
REKDKIYKNLKDRF

Download         Length: 285 bp

>T158102 NZ_CP069571:2017579-2017986 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTAGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9240.60 Da        Isoelectric Point: 4.3696

>AT158102 WP_014468874.1 NZ_CP053835:c1329387-1329136 [Arcobacter defluvii]
MQPILANYSASITELKKSPTQLLNEADNEVIAILNHNIPSAYLVPSKLYEKMMDIIDDYHLSLEVGKALNDGEKPVKVSL
DDL

Download         Length: 252 bp

>AT158102 NZ_CP069571:2017332-2017598 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G9JVW9

Antitoxin

Source ID Structure
AlphaFold DB A0A0G9JP98

References