Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1001946..1002520 Replicon chromosome
Accession NZ_CP053833
Organism Arcobacter cloacae strain LMG 26153

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ACLO_RS05095 Protein ID WP_129012588.1
Coordinates 1001946..1002281 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ACLO_RS05100 Protein ID WP_129012589.1
Coordinates 1002275..1002520 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACLO_RS05070 997079..997495 - 417 WP_129012585.1 DUF721 domain-containing protein -
ACLO_RS05075 997466..997612 + 147 WP_164967033.1 hypothetical protein -
ACLO_RS05080 997609..999063 + 1455 WP_128985552.1 FAD-binding protein -
ACLO_RS05085 999187..1000722 + 1536 WP_129012586.1 glutamine-hydrolyzing GMP synthase -
ACLO_RS05090 1000930..1001892 + 963 WP_129012587.1 hypothetical protein -
ACLO_RS05095 1001946..1002281 - 336 WP_129012588.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ACLO_RS05100 1002275..1002520 - 246 WP_129012589.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ACLO_RS05105 1002651..1003112 + 462 WP_129012590.1 hypothetical protein -
ACLO_RS05110 1003305..1005002 - 1698 WP_129012591.1 YdiU family protein -
ACLO_RS05115 1005002..1005805 - 804 WP_129012592.1 DnaJ domain-containing protein -
ACLO_RS05120 1005974..1007338 + 1365 WP_129012593.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 989628..1268161 278533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-103)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12531.69 Da        Isoelectric Point: 10.1692

>T158100 WP_129012588.1 NZ_CP053833:c1002281-1001946 [Arcobacter cloacae]
MVKNYIPKKGDLVILSFDPSSGHEQKGRRPALIISNEIFNKALGLAIACPITNTDRNFPFHVKLEAKNLKGFIMTEQIKS
IDFNARKVKFVEKIDEDTLNQVLGITKSIIF

Download         Length: 336 bp

>T158100 NZ_CP069571:1829807-1830103 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9211.53 Da        Isoelectric Point: 4.4678

>AT158100 WP_129012589.1 NZ_CP053833:c1002520-1002275 [Arcobacter cloacae]
MTAKISKWGNSQGLRMPKDVMESLHLNVGDDVNIIVFDGKVILEPIKKEILNYDLNELVSKIPSDYKASEEFDTTVGKEE
W

Download         Length: 246 bp

>AT158100 NZ_CP069571:1830105-1830500 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References