Detailed information of TA system TA158099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1883885..1884543
• Replicon: chromosome
• Accession: NZ_CP053826
• Organism: Campylobacter curvus strain ATCC 35224

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CCVT_RS09305
• Protein ID: WP_018137147.1
• Coordinates: 1883885..1884292 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A7D3QZX2
• Locus tag: CCVT_RS09310
• Protein ID: WP_018137148.1
• Coordinates: 1884292..1884543 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCVT_RS09280	1878893..1879738	+	846	WP_018137141.1	dimethyl sulfoxide reductase anchor subunit	-
CCVT_RS09285	1879735..1880385	+	651	WP_018137142.1	molecular chaperone TorD family protein	-
CCVT_RS09290	1880523..1881395	+	873	WP_169331156.1	4Fe-4S binding protein	-
CCVT_RS09295	1881404..1882177	+	774	WP_018137144.1	AraC family transcriptional regulator	-
CCVT_RS09300	1882181..1883434	+	1254	WP_018137145.1	radical SAM protein	-
CCVT_RS09305	1883885..1884292	-	408	WP_018137147.1	type II toxin-antitoxin system VapC family toxin	Toxin
CCVT_RS09310	1884292..1884543	-	252	WP_018137148.1	hypothetical protein	Antitoxin
CCVT_RS09315	1885095..1886510	+	1416	WP_018137150.1	hypothetical protein	-
CCVT_RS09320	1886635..1887126	-	492	WP_155827527.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• SpoVT-AbrB domain (8-56)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15457.80 Da
• Isoelectric Point: 5.7382

>T158099 WP_018137147.1 NZ_CP053826:c1884292-1883885 [Campylobacter curvus]
MFLLDTNICSYLISSTEPYSQNILSHLTKHGKKDIFISSITIAEMFYGIENSTQKELNLRLMSDFISNFGVLDFTSKCAA
SYGKIRLEMRNKNRRIGDMDMLIAAVALSNDLVLVTNNEKDFKDISELRMENWSI

Nucleotide

• Length: 408 bp

>T158099 NZ_CP069571:1765233-1765547 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9540.01 Da
• Isoelectric Point: 9.8437

>AT158099 WP_018137148.1 NZ_CP053826:c1884543-1884292 [Campylobacter curvus]
MQVRLKVFKSGNSLALRLPKSLNLDNVKEFILKSFDNNEVILTPVKDDEWSGLFKTLNELKDAGVKFERAEPSLPQERNF
GFK

Nucleotide

• Length: 252 bp

>AT158099 NZ_CP069571:1765544-1765960 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A7D3QZX2