Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 525971..526737 Replicon chromosome
Accession NZ_CP053823
Organism Vibrio cholerae strain E7G

Toxin (Protein)


Gene name - Uniprot ID A0A233HKB4
Locus tag HPY10_RS16675 Protein ID WP_000982256.1
Coordinates 525971..526468 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0Q0PQR2
Locus tag HPY10_RS16680 Protein ID WP_000246255.1
Coordinates 526465..526737 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY10_RS16635 521442..521714 - 273 WP_001915058.1 DUF1778 domain-containing protein -
HPY10_RS16640 521945..522460 + 516 WP_114721773.1 lipocalin family protein -
HPY10_RS16645 523114..523371 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY10_RS16650 523359..523661 + 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY10_RS16655 523816..524133 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY10_RS16660 524152..524394 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY10_RS16665 524789..525178 + 390 WP_175242351.1 VOC family protein -
HPY10_RS16670 525373..525696 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY10_RS16675 525971..526468 - 498 WP_000982256.1 GNAT family N-acetyltransferase Toxin
HPY10_RS16680 526465..526737 - 273 WP_000246255.1 DUF1778 domain-containing protein Antitoxin
HPY10_RS16685 526968..527444 + 477 WP_001047188.1 GNAT family N-acetyltransferase -
HPY10_RS16690 527688..528161 - 474 WP_000034755.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
HPY10_RS16695 528383..528997 + 615 WP_175246457.1 OmpA family protein -
HPY10_RS16700 529231..530793 + 1563 WP_175246458.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..527444 217390
- inside Integron - - 311218..527444 216226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18539.23 Da        Isoelectric Point: 8.7753

>T158098 WP_000982256.1 NZ_CP053823:c526468-525971 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T158098 NZ_CP069571:1304524-1304631 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9713.24 Da        Isoelectric Point: 6.2988

>AT158098 WP_000246255.1 NZ_CP053823:c526737-526465 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT158098 NZ_CP069571:c1304476-1304410 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A233HKB4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0PQR2

References