Detailed information of TA system TA158096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 523114..523661
• Replicon: chromosome
• Accession: NZ_CP053823
• Organism: Vibrio cholerae strain E7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0Q0PYS1
• Locus tag: HPY10_RS16650
• Protein ID: WP_000229322.1
• Coordinates: 523359..523661 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: HPY10_RS16645
• Protein ID: WP_000861987.1
• Coordinates: 523114..523371 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY10_RS16605	518159..518395	+	237	WP_081447723.1	DUF3709 domain-containing protein	-
HPY10_RS16610	518675..519100	+	426	WP_061051384.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
HPY10_RS16615	519230..519685	+	456	WP_095457989.1	GNAT family N-acetyltransferase	-
HPY10_RS16620	519742..519834	+	93	WP_175246454.1	acetyltransferase	-
HPY10_RS16625	519831..520499	+	669	WP_175246455.1	hypothetical protein	-
HPY10_RS16630	520948..521445	-	498	WP_175246456.1	GNAT family N-acetyltransferase	-
HPY10_RS16635	521442..521714	-	273	WP_001915058.1	DUF1778 domain-containing protein	-
HPY10_RS16640	521945..522460	+	516	WP_114721773.1	lipocalin family protein	-
HPY10_RS16645	523114..523371	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY10_RS16650	523359..523661	+	303	WP_000229322.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY10_RS16655	523816..524133	-	318	WP_001180243.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY10_RS16660	524152..524394	-	243	WP_001961623.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY10_RS16665	524789..525178	+	390	WP_175242351.1	VOC family protein	-
HPY10_RS16670	525373..525696	+	324	WP_080299109.1	DUF3709 domain-containing protein	-
HPY10_RS16675	525971..526468	-	498	WP_000982256.1	GNAT family N-acetyltransferase	-
HPY10_RS16680	526465..526737	-	273	WP_000246255.1	DUF1778 domain-containing protein	-
HPY10_RS16685	526968..527444	+	477	WP_001047188.1	GNAT family N-acetyltransferase	-
HPY10_RS16690	527688..528161	-	474	WP_000034755.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	310054..527444	217390
	-	inside	Integron	-	-	311218..527444	216226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11737.67 Da
• Isoelectric Point: 5.1972

>T158096 WP_000229322.1 NZ_CP053823:523359-523661 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T158096 NZ_CP069571:1303558-1303665 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT158096 WP_000861987.1 NZ_CP053823:523114-523371 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT158096 NZ_CP069571:c1303500-1303444 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A0Q0PYS1

Antitoxin

• AlphaFold DB: A0A1T4SLM9