Detailed information of TA system TA158090

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 466629..467176
• Replicon: chromosome
• Accession: NZ_CP053823
• Organism: Vibrio cholerae strain E7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY10_RS16200
• Protein ID: WP_071187828.1
• Coordinates: 466874..467176 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY10_RS16195
• Protein ID: WP_055031549.1
• Coordinates: 466629..466886 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY10_RS16150	461675..462682	+	1008	WP_175246433.1	hypothetical protein	-
HPY10_RS16155	462752..462871	+	120	WP_114780049.1	acetyltransferase	-
HPY10_RS16160	462812..463129	-	318	WP_148532547.1	CcdB family protein	-
HPY10_RS16165	463129..463374	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY10_RS16170	463729..463872	+	144	Protein_525	DUF645 family protein	-
HPY10_RS16175	464036..464671	+	636	WP_175246434.1	DUF2807 domain-containing protein	-
HPY10_RS16180	464830..465306	+	477	WP_175246430.1	DM13 domain-containing protein	-
HPY10_RS16185	465468..465893	+	426	WP_061051384.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
HPY10_RS16190	466052..466438	+	387	WP_123011595.1	NUDIX hydrolase	-
HPY10_RS16195	466629..466886	+	258	WP_055031549.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY10_RS16200	466874..467176	+	303	WP_071187828.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY10_RS16205	467494..468126	+	633	WP_175246435.1	FRG domain-containing protein	-
HPY10_RS16210	468269..469132	+	864	WP_175246436.1	hypothetical protein	-
HPY10_RS16215	469304..470056	+	753	WP_114720911.1	SDR family oxidoreductase	-
HPY10_RS16220	470333..470506	+	174	WP_175246437.1	DUF3709 domain-containing protein	-
HPY10_RS16225	470838..471686	+	849	WP_175246438.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	310054..527444	217390
	-	inside	Integron	-	-	311218..527444	216226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11694.60 Da
• Isoelectric Point: 5.8741

>T158090 WP_071187828.1 NZ_CP053823:466874-467176 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELKHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T158090 NZ_CP069570:c18008-17628 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACGGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGCGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9619.14 Da
• Isoelectric Point: 7.3176

>AT158090 WP_055031549.1 NZ_CP053823:466629-466886 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT158090 NZ_CP069570:c18229-18008 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA