Detailed information of TA system TA158089

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 460306..460865
• Replicon: chromosome
• Accession: NZ_CP053823
• Organism: Vibrio cholerae strain E7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D2YI11
• Locus tag: HPY10_RS16140
• Protein ID: WP_000578473.1
• Coordinates: 460306..460584 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY10_RS16145
• Protein ID: WP_000381186.1
• Coordinates: 460581..460865 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY10_RS16085	455726..455822	+	97	Protein_508	DUF645 family protein	-
HPY10_RS16090	456178..456360	+	183	WP_071170650.1	DUF645 family protein	-
HPY10_RS16095	456566..456904	+	339	WP_175246331.1	hypothetical protein	-
HPY10_RS16100	457059..457424	+	366	WP_069730855.1	hypothetical protein	-
HPY10_RS16105	457570..458370	+	801	WP_114763308.1	nucleotide-binding protein	-
HPY10_RS16110	458361..458477	+	117	WP_114763309.1	DUF3265 domain-containing protein	-
HPY10_RS16115	458517..458792	+	276	WP_000436062.1	hypothetical protein	-
HPY10_RS16120	458972..459142	+	171	WP_001080654.1	hypothetical protein	-
HPY10_RS16125	459142..459543	+	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	-
HPY10_RS16130	459530..459703	+	174	WP_175246605.1	DUF3265 domain-containing protein	-
HPY10_RS16135	459678..460166	+	489	WP_044128169.1	GNAT family N-acetyltransferase	-
HPY10_RS16140	460306..460584	-	279	WP_000578473.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPY10_RS16145	460581..460865	-	285	WP_000381186.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPY10_RS16150	461675..462682	+	1008	WP_175246433.1	hypothetical protein	-
HPY10_RS16155	462752..462871	+	120	WP_114780049.1	acetyltransferase	-
HPY10_RS16160	462812..463129	-	318	WP_148532547.1	CcdB family protein	-
HPY10_RS16165	463129..463374	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY10_RS16170	463729..463872	+	144	Protein_525	DUF645 family protein	-
HPY10_RS16175	464036..464671	+	636	WP_175246434.1	DUF2807 domain-containing protein	-
HPY10_RS16180	464830..465306	+	477	WP_175246430.1	DM13 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	310054..527444	217390
	-	inside	Integron	-	-	311218..527444	216226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10868.59 Da
• Isoelectric Point: 4.6794

>T158089 WP_000578473.1 NZ_CP053823:c460584-460306 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T158089 NZ_CP069569:26860-27414 [Corynebacterium sp. FDAARGOS 1242]
GTGAGTGGCTTTACCGTTATCTACGACGCCAACGTGCTGTACCCCAATATGTTGCGTGACATCCTGATCCGACTGGCAGG
CACGGGCATTTACCAAGCCCGGTGGACTGAGGACATCCTGGATGAGGTTTTTCGCAACCTCCAGGCCAACCGGCCAGATC
TTGACCCCAGTAAACTACGCCGAACCCGGGAGCTGATGTGTCGGGCTGTGGATGATTGTCTGGTGACTGGGTATGAAGAT
TTAATTGAGTCATTGTCCTTGCCGGATCCTGATGACCGTCATGTTCTTGCTGCTGCCATCAGGTGTGGTGCCCAGGTGAT
TGTCACCGAAAACGCGCGGGATTTTCCTCAAGACGTGATGGATAAATACGGCATCGAGATCCAGGGTGCTGATGAGTTTT
TATGTGATCAGATTGATCTGTTCGGTACTCGTGTCCATCAGGCTATTACCTATGCCGCGGCGGCGTTCAAAAATCCCCCC
ATGACCATTGATGATGTACTTGACGCGCTAGCCAGGGCGGGAGCTCCTTCCGCAGCGGACTTACTCCGGAGATAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10915.28 Da
• Isoelectric Point: 8.0775

>AT158089 WP_000381186.1 NZ_CP053823:c460865-460581 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT158089 NZ_CP069569:26414-26863 [Corynebacterium sp. FDAARGOS 1242]
ATGGCCTATCTACAAGACAACGAAATCGCTAGCACTGCGGCCACAGCCCGTGAGGCTTTGCAGAAAATCAATCGCGTCCT
AAGCGATACATCTACCAATAAGGACGTCAAGGTCGTAGTGGAGCAGTCTGATGAGGTCATCCGTCTACCCAGAGAAGTCG
CCACCGTCCTCCGGGAAATCCTGGTCAATTCAGTAGCCGGCAGATCGGTAAGCGTGATCCCCATGCGGGCCGAGCTAACC
ACCCAGCAAGCAGCTAACCTGCTTAATGTTTCTCGTCCGCATGTCATTAAATTGATGGATGACGGCATCTTGCCTGGACA
TAAGGTTGGTACTCATCGACGTATCTATGCGGCCGACGTGCAGGCCTATAAACACCAACGAGATATCGAGGCACGTACAG
CTGCAGATGATCTCACCGCCCTAACCGAGGAGATGGGGCTGTACGAGTGA

Structures

Toxin

• AlphaFold DB: D2YI11