Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
| Location | 458972..459543 | Replicon | chromosome |
| Accession | NZ_CP053823 | ||
| Organism | Vibrio cholerae strain E7G | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9KMA2 |
| Locus tag | HPY10_RS16125 | Protein ID | WP_000351248.1 |
| Coordinates | 459142..459543 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q8GNG3 |
| Locus tag | HPY10_RS16120 | Protein ID | WP_001080654.1 |
| Coordinates | 458972..459142 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY10_RS16085 | 455726..455822 | + | 97 | Protein_508 | DUF645 family protein | - |
| HPY10_RS16090 | 456178..456360 | + | 183 | WP_071170650.1 | DUF645 family protein | - |
| HPY10_RS16095 | 456566..456904 | + | 339 | WP_175246331.1 | hypothetical protein | - |
| HPY10_RS16100 | 457059..457424 | + | 366 | WP_069730855.1 | hypothetical protein | - |
| HPY10_RS16105 | 457570..458370 | + | 801 | WP_114763308.1 | nucleotide-binding protein | - |
| HPY10_RS16110 | 458361..458477 | + | 117 | WP_114763309.1 | DUF3265 domain-containing protein | - |
| HPY10_RS16115 | 458517..458792 | + | 276 | WP_000436062.1 | hypothetical protein | - |
| HPY10_RS16120 | 458972..459142 | + | 171 | WP_001080654.1 | hypothetical protein | Antitoxin |
| HPY10_RS16125 | 459142..459543 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| HPY10_RS16130 | 459530..459703 | + | 174 | WP_175246605.1 | DUF3265 domain-containing protein | - |
| HPY10_RS16135 | 459678..460166 | + | 489 | WP_044128169.1 | GNAT family N-acetyltransferase | - |
| HPY10_RS16140 | 460306..460584 | - | 279 | WP_000578473.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| HPY10_RS16145 | 460581..460865 | - | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY10_RS16150 | 461675..462682 | + | 1008 | WP_175246433.1 | hypothetical protein | - |
| HPY10_RS16155 | 462752..462871 | + | 120 | WP_114780049.1 | acetyltransferase | - |
| HPY10_RS16160 | 462812..463129 | - | 318 | WP_148532547.1 | CcdB family protein | - |
| HPY10_RS16165 | 463129..463374 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| HPY10_RS16170 | 463729..463872 | + | 144 | Protein_525 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 310054..527444 | 217390 | |
| - | inside | Integron | - | - | 311218..527444 | 216226 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14608.71 Da Isoelectric Point: 4.0128
>T158088 WP_000351248.1 NZ_CP053823:459142-459543 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T158088 NZ_CP069568:c1358824-1358543 [Corynebacterium sp. FDAARGOS 1242]
ATGATCCAGTCGTTTGCTAACCGAGACACCGAGCTTGTCTGGTTGCGCCAAGCGTCACCCCGGATTGATTCGAGAATCCA
CAAGACTGCAAATAGAAAACTTCATCAGCTTGATGCAGCAGTTTCCCTGCAATCGCTGCGTGTTCCGCCGGGGAACCGAT
TGGAAGCTTTAAAAGGTGATCGAAAGGGGATGTACAGCATTCGAGTCAATCAACAATGGAGGATTACTTTTCGCTGGACC
GAAGCGGGCCCGGCGGATGTGGCAATAGAGGATTATCACTAA
ATGATCCAGTCGTTTGCTAACCGAGACACCGAGCTTGTCTGGTTGCGCCAAGCGTCACCCCGGATTGATTCGAGAATCCA
CAAGACTGCAAATAGAAAACTTCATCAGCTTGATGCAGCAGTTTCCCTGCAATCGCTGCGTGTTCCGCCGGGGAACCGAT
TGGAAGCTTTAAAAGGTGATCGAAAGGGGATGTACAGCATTCGAGTCAATCAACAATGGAGGATTACTTTTCGCTGGACC
GAAGCGGGCCCGGCGGATGTGGCAATAGAGGATTATCACTAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6287.35 Da Isoelectric Point: 10.7274
>AT158088 WP_001080654.1 NZ_CP053823:458972-459142 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT158088 NZ_CP069568:c1358534-1358235 [Corynebacterium sp. FDAARGOS 1242]
ATGAGTACCAAGTTGTATCCACCTATTCATCCTGGAGAAGTGCTCAACGAAGACTTCATTAAGGCATTTGGGATTACCCA
GCATAAGTTAGCTATGGCCATTGGAGTCCCACCGCGCAGGATTAACGAGATCGTCCACGGCAAGCGCGGAATTACAGCAG
ACACTGCGCTGCGCTTAGGAAGGTATTTCGGGGTAGAACCGCAGTTCTGGGTGAACTTGCAAGGACGATACGAGCTCGAA
CTAGCAGAGGATTCAATAGCTGAAGAAGTTAGCAGTATTGAGCCGCTCGAAGTGGCCTGA
ATGAGTACCAAGTTGTATCCACCTATTCATCCTGGAGAAGTGCTCAACGAAGACTTCATTAAGGCATTTGGGATTACCCA
GCATAAGTTAGCTATGGCCATTGGAGTCCCACCGCGCAGGATTAACGAGATCGTCCACGGCAAGCGCGGAATTACAGCAG
ACACTGCGCTGCGCTTAGGAAGGTATTTCGGGGTAGAACCGCAGTTCTGGGTGAACTTGCAAGGACGATACGAGCTCGAA
CTAGCAGAGGATTCAATAGCTGAAGAAGTTAGCAGTATTGAGCCGCTCGAAGTGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0PN34 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SJJ1 |