Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 447442..447989 Replicon chromosome
Accession NZ_CP053823
Organism Vibrio cholerae strain E7G

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0PYS1
Locus tag HPY10_RS16025 Protein ID WP_000229322.1
Coordinates 447687..447989 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag HPY10_RS16020 Protein ID WP_000861987.1
Coordinates 447442..447699 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY10_RS15980 442560..442865 - 306 WP_024699541.1 helix-turn-helix domain-containing protein -
HPY10_RS15985 442874..443197 - 324 WP_024699542.1 hypothetical protein -
HPY10_RS15990 443622..443849 - 228 WP_024699543.1 hypothetical protein -
HPY10_RS15995 444227..444640 + 414 WP_175242843.1 VOC family protein -
HPY10_RS16000 444801..445256 + 456 WP_000432865.1 hypothetical protein -
HPY10_RS16005 445532..446113 + 582 WP_175246604.1 hypothetical protein -
HPY10_RS16010 446591..446701 + 111 WP_086017781.1 DUF3265 domain-containing protein -
HPY10_RS16015 446728..447243 + 516 WP_114721773.1 lipocalin family protein -
HPY10_RS16020 447442..447699 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY10_RS16025 447687..447989 + 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY10_RS16030 448065..448259 + 195 WP_175246427.1 DUF3709 domain-containing protein -
HPY10_RS16035 448253..448501 + 249 WP_082069824.1 DUF3709 domain-containing protein -
HPY10_RS16040 448876..449301 + 426 WP_033928096.1 hypothetical protein -
HPY10_RS16045 449479..450249 + 771 WP_175246429.1 alpha/beta hydrolase -
HPY10_RS16050 450401..450814 + 414 WP_055064865.1 NUDIX domain-containing protein -
HPY10_RS16055 450956..451393 + 438 WP_172779930.1 NUDIX pyrophosphatase -
HPY10_RS16060 451875..451985 + 111 WP_175246598.1 DUF3265 domain-containing protein -
HPY10_RS16065 452014..452520 + 507 WP_123011681.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..527444 217390
- inside Integron - - 311218..527444 216226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11737.67 Da        Isoelectric Point: 5.1972

>T158087 WP_000229322.1 NZ_CP053823:447687-447989 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T158087 NZ_CP069567:584372-584722 [Staphylococcus condimenti]
ATGATGAGGAGAGGCGATGTTTACTTAGCTGATTTATCGCCAGTGCAAGGTTCTGAACAAGGGGGAGTTAGGCCTGTTGT
AATTATACAAAACGACACTGGAAATAAGTATAGTCCAACAGTCATTGTAGCTGCAATGACTGGACGGATTAATAAAGCAA
AAATTCCTACTCATGTTGAAATTGAAAAAAGTAAATATAAATTGGACAAAGATTCAGTTATTTTACTAGAACAGATAAGA
ACAGTCGATAAAAAGCGACTTAAAGAAAAACTGACATATTTATCAGACGAAAAGATGAAAGAAATTGATAATGCGATTCA
AATCAGCTTAGGCTTGACACATCGCAATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT158087 WP_000861987.1 NZ_CP053823:447442-447699 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT158087 NZ_CP069567:584208-584375 [Staphylococcus condimenti]
ATGTCAACTTTTAATCAGAATAGAAGTTATAGTTTAGAACAGTCACTGAAAGAAGGCTATGCACAGATGGCTGACTTAAA
TCTCTCCCTCGCAACGGAGGCATTTTCAGTAGAATGTGAAGCCTGTGATTGCAATGAATCATATTTAGCTTTTGACAAGG
ATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PYS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References