Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 435829..436394 Replicon chromosome
Accession NZ_CP053823
Organism Vibrio cholerae strain E7G

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag HPY10_RS15915 Protein ID WP_000869999.1
Coordinates 436107..436394 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag HPY10_RS15910 Protein ID WP_000086649.1
Coordinates 435829..436110 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY10_RS15860 430984..431271 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY10_RS15865 431498..431764 + 267 WP_175246421.1 hypothetical protein -
HPY10_RS15870 431939..432334 + 396 WP_175246422.1 DUF3465 domain-containing protein -
HPY10_RS15875 432461..432622 + 162 WP_175246423.1 hypothetical protein -
HPY10_RS15880 432811..432921 + 111 WP_175246602.1 DUF3265 domain-containing protein -
HPY10_RS15885 432965..433324 + 360 WP_076025909.1 VOC family protein -
HPY10_RS15890 433493..433969 + 477 WP_175246603.1 DUF2059 domain-containing protein -
HPY10_RS15895 434169..434963 - 795 WP_175246424.1 NYN domain-containing protein -
HPY10_RS15900 435050..435205 + 156 WP_175246425.1 DUF3265 domain-containing protein -
HPY10_RS15905 435457..435570 + 114 Protein_472 DUF645 family protein -
HPY10_RS15910 435829..436110 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY10_RS15915 436107..436394 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY10_RS15920 436574..437077 + 504 WP_001158952.1 DinB family protein -
HPY10_RS15925 437444..437553 + 110 Protein_476 DUF645 family protein -
HPY10_RS15930 437755..438132 + 378 WP_055028395.1 hypothetical protein -
HPY10_RS15935 438134..438424 + 291 WP_055028394.1 hypothetical protein -
HPY10_RS15940 438428..438596 + 169 Protein_479 DUF3265 domain-containing protein -
HPY10_RS15945 438580..439461 + 882 WP_175247672.1 restriction endonuclease -
HPY10_RS15950 439431..439575 + 145 Protein_481 DUF3265 domain-containing protein -
HPY10_RS15955 439610..440086 + 477 WP_175246430.1 DM13 domain-containing protein -
HPY10_RS15960 440221..440538 + 318 WP_175246431.1 hypothetical protein -
HPY10_RS15965 440780..441205 + 426 WP_114808311.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..527444 217390
- inside Integron - - 311218..527444 216226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T158086 WP_000869999.1 NZ_CP053823:436107-436394 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T158086 NZ_CP069567:571167-571373 [Staphylococcus condimenti]
ATGCAAAACAGTGTAATTAAAATTGATGGAATGGAAACTGAAGAAGAACAGCATAAATTACATCAACATCTTATAGAAAT
GACAGGTGTAACTGCAGTACAAGTAGATTTGGATTCAAATGAAATCAAAATCAGTTACGAAACACCTGTAAATCTCAATA
ATCTTGAAAAAGAAATCTATGATGCGGGTTATCAAATATTAAATTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT158086 WP_000086649.1 NZ_CP053823:435829-436110 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT158086 NZ_CP069567:570862-571155 [Staphylococcus condimenti]
ATGACCGAAAATGACAAAGCACATCATTCAGAACAAATTAAGTCCAACTTGAAAGCAAGACTCAACCGTATTGAGGGGCA
AGTCAGAGCAATTAACCGAATGATTGAAGAAGATGTTTATTGTGATGATGTACTTACACAAATCCGTGCAACACGTTCAG
CCTTGAACAGTGTAGCAGTACGATTGCTTGATCACCATATGAAAGGTTGTATCATGCATAAAGTTGAGGATGGTCACGCT
GAAGAAGCAATGGAAGAATTGCTTGTTACCGTTCAAAAATTAATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References