Detailed information of TA system TA158084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 405573..406071
• Replicon: chromosome
• Accession: NZ_CP053823
• Organism: Vibrio cholerae strain E7G

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK7
• Locus tag: HPY10_RS15630
• Protein ID: WP_000589156.1
• Coordinates: 405573..405839 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK6
• Locus tag: HPY10_RS15635
• Protein ID: WP_000643598.1
• Coordinates: 405826..406071 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY10_RS15590	400971..401408	+	438	WP_172779930.1	NUDIX pyrophosphatase	-
HPY10_RS15595	401477..401545	+	69	Protein_410	acetyltransferase	-
HPY10_RS15600	401558..402496	+	939	WP_175247606.1	hypothetical protein	-
HPY10_RS15605	402616..402904	+	289	Protein_412	DUF1289 domain-containing protein	-
HPY10_RS15610	403159..403860	+	702	WP_001175917.1	hypothetical protein	-
HPY10_RS15615	404493..404903	+	411	WP_025613414.1	cytidine deaminase	-
HPY10_RS15620	404873..405010	+	138	WP_175246445.1	DUF3265 domain-containing protein	-
HPY10_RS15625	405049..405396	+	348	WP_175247665.1	hypothetical protein	-
HPY10_RS15630	405573..405839	+	267	WP_000589156.1	BrnT family toxin	Toxin
HPY10_RS15635	405826..406071	+	246	WP_000643598.1	hypothetical protein	Antitoxin
HPY10_RS15640	406215..406988	+	774	WP_175247666.1	aminoglycoside phosphotransferase family protein	-
HPY10_RS15645	407283..407504	+	222	Protein_420	DUF645 family protein	-
HPY10_RS15650	407874..408191	-	318	WP_175247667.1	CcdB family protein	-
HPY10_RS15655	408191..408436	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY10_RS15660	408846..409163	-	318	WP_175247667.1	CcdB family protein	-
HPY10_RS15665	409163..409408	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY10_RS15670	409988..410092	+	105	WP_175247668.1	DUF3265 domain-containing protein	-
HPY10_RS15675	410079..410465	+	387	WP_001015087.1	MmcQ/YjbR family DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	310054..527444	217390
	-	inside	Integron	-	-	311218..527444	216226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10092.34 Da
• Isoelectric Point: 7.3171

>T158084 WP_000589156.1 NZ_CP053823:405573-405839 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Nucleotide

• Length: 267 bp

>T158084 NZ_CP069565:c1547318-1547223 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9478.77 Da
• Isoelectric Point: 6.4832

>AT158084 WP_000643598.1 NZ_CP053823:405826-406071 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Nucleotide

• Length: 246 bp

>AT158084 NZ_CP069565:1547136-1547195 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Toxin

• AlphaFold DB: A0A271VMP7

Antitoxin

• AlphaFold DB: A0A271VME2