Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 388408..388967 Replicon chromosome
Accession NZ_CP053823
Organism Vibrio cholerae strain E7G

Toxin (Protein)


Gene name relE Uniprot ID D7HHK2
Locus tag HPY10_RS15475 Protein ID WP_000578471.1
Coordinates 388408..388686 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag HPY10_RS15480 Protein ID WP_000381183.1
Coordinates 388683..388967 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY10_RS15430 384071..384160 + 90 WP_141239104.1 DUF645 family protein -
HPY10_RS15435 384160..384252 + 93 Protein_378 DUF645 family protein -
HPY10_RS15440 384449..385078 + 630 WP_052259807.1 hypothetical protein -
HPY10_RS15445 385551..385661 + 111 WP_084980740.1 DUF3265 domain-containing protein -
HPY10_RS15450 385698..386030 + 333 WP_138041757.1 YggL family protein -
HPY10_RS15455 386168..386710 + 543 WP_142738652.1 yfeABCD locus regulator -
HPY10_RS15460 387020..387199 + 180 Protein_383 DUF645 family protein -
HPY10_RS15465 387779..387850 + 72 WP_170320369.1 hypothetical protein -
HPY10_RS15470 387971..388207 + 237 WP_175247186.1 DUF645 family protein -
HPY10_RS15475 388408..388686 - 279 WP_000578471.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPY10_RS15480 388683..388967 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY10_RS15485 389324..389410 + 87 WP_134820423.1 DUF645 family protein -
HPY10_RS15490 389410..389502 + 93 Protein_389 DUF645 family protein -
HPY10_RS15495 389769..390059 + 291 WP_175247656.1 YkgJ family cysteine cluster protein -
HPY10_RS15500 390235..390591 + 357 WP_175247657.1 hypothetical protein -
HPY10_RS15505 390768..391139 + 372 WP_001008376.1 hypothetical protein -
HPY10_RS15510 391311..392111 + 801 WP_002045689.1 PhzF family phenazine biosynthesis protein -
HPY10_RS15515 392368..392544 + 177 WP_175247605.1 hypothetical protein -
HPY10_RS15520 392584..393504 - 921 WP_175247658.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..527444 217390
- inside Integron - - 311218..527444 216226
- flank IS/Tn - - 392584..393504 920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10838.56 Da        Isoelectric Point: 4.6794

>T158083 WP_000578471.1 NZ_CP053823:c388686-388408 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T158083 NZ_CP069565:1489318-1489470 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT158083 WP_000381183.1 NZ_CP053823:c388967-388683 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT158083 NZ_CP069565:1488694-1489293 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References