Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 388408..388967 | Replicon | chromosome |
| Accession | NZ_CP053823 | ||
| Organism | Vibrio cholerae strain E7G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HHK2 |
| Locus tag | HPY10_RS15475 | Protein ID | WP_000578471.1 |
| Coordinates | 388408..388686 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | HPY10_RS15480 | Protein ID | WP_000381183.1 |
| Coordinates | 388683..388967 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY10_RS15430 | 384071..384160 | + | 90 | WP_141239104.1 | DUF645 family protein | - |
| HPY10_RS15435 | 384160..384252 | + | 93 | Protein_378 | DUF645 family protein | - |
| HPY10_RS15440 | 384449..385078 | + | 630 | WP_052259807.1 | hypothetical protein | - |
| HPY10_RS15445 | 385551..385661 | + | 111 | WP_084980740.1 | DUF3265 domain-containing protein | - |
| HPY10_RS15450 | 385698..386030 | + | 333 | WP_138041757.1 | YggL family protein | - |
| HPY10_RS15455 | 386168..386710 | + | 543 | WP_142738652.1 | yfeABCD locus regulator | - |
| HPY10_RS15460 | 387020..387199 | + | 180 | Protein_383 | DUF645 family protein | - |
| HPY10_RS15465 | 387779..387850 | + | 72 | WP_170320369.1 | hypothetical protein | - |
| HPY10_RS15470 | 387971..388207 | + | 237 | WP_175247186.1 | DUF645 family protein | - |
| HPY10_RS15475 | 388408..388686 | - | 279 | WP_000578471.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| HPY10_RS15480 | 388683..388967 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HPY10_RS15485 | 389324..389410 | + | 87 | WP_134820423.1 | DUF645 family protein | - |
| HPY10_RS15490 | 389410..389502 | + | 93 | Protein_389 | DUF645 family protein | - |
| HPY10_RS15495 | 389769..390059 | + | 291 | WP_175247656.1 | YkgJ family cysteine cluster protein | - |
| HPY10_RS15500 | 390235..390591 | + | 357 | WP_175247657.1 | hypothetical protein | - |
| HPY10_RS15505 | 390768..391139 | + | 372 | WP_001008376.1 | hypothetical protein | - |
| HPY10_RS15510 | 391311..392111 | + | 801 | WP_002045689.1 | PhzF family phenazine biosynthesis protein | - |
| HPY10_RS15515 | 392368..392544 | + | 177 | WP_175247605.1 | hypothetical protein | - |
| HPY10_RS15520 | 392584..393504 | - | 921 | WP_175247658.1 | IS5 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 310054..527444 | 217390 | |
| - | inside | Integron | - | - | 311218..527444 | 216226 | |
| - | flank | IS/Tn | - | - | 392584..393504 | 920 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10838.56 Da Isoelectric Point: 4.6794
>T158083 WP_000578471.1 NZ_CP053823:c388686-388408 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T158083 NZ_CP069565:1489318-1489470 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT158083 WP_000381183.1 NZ_CP053823:c388967-388683 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT158083 NZ_CP069565:1488694-1489293 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VKS2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |