Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 377556..378096 Replicon chromosome
Accession NZ_CP053823
Organism Vibrio cholerae strain E7G

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag HPY10_RS15385 Protein ID WP_000277238.1
Coordinates 377556..377825 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag HPY10_RS15390 Protein ID WP_001258569.1
Coordinates 377818..378096 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY10_RS15340 373273..374184 + 912 WP_175247652.1 hypothetical protein -
HPY10_RS15345 374196..374366 + 171 WP_175247653.1 hypothetical protein -
HPY10_RS15350 374585..374866 + 282 WP_175247654.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY10_RS15355 374863..375150 + 288 WP_175247655.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY10_RS15360 375308..375772 + 465 WP_076025888.1 ASCH domain-containing protein -
HPY10_RS15365 375837..375920 + 84 Protein_364 disulfide bond formation protein DsbD -
HPY10_RS15370 375918..376334 + 417 WP_069730442.1 DUF1311 domain-containing protein -
HPY10_RS15375 376652..376870 + 219 Protein_366 DUF645 family protein -
HPY10_RS15380 377066..377302 - 237 WP_000772130.1 RNA-binding protein -
HPY10_RS15385 377556..377825 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
HPY10_RS15390 377818..378096 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY10_RS15395 378850..379590 + 741 WP_162813548.1 PhzF family phenazine biosynthesis protein -
HPY10_RS15400 379774..380187 + 414 WP_175246413.1 VOC family protein -
HPY10_RS15405 380255..380368 + 114 WP_081018724.1 acetyltransferase -
HPY10_RS15410 380317..380598 + 282 WP_001894429.1 DUF1289 domain-containing protein -
HPY10_RS15415 381090..381698 + 609 WP_032474141.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..527444 217390
- inside Integron - - 311218..527444 216226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T158082 WP_000277238.1 NZ_CP053823:c377825-377556 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T158082 NZ_CP069565:1386030-1386206 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT158082 WP_001258569.1 NZ_CP053823:c378096-377818 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT158082 NZ_CP069565:c1386368-1386194 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References