Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 374585..375150 Replicon chromosome
Accession NZ_CP053823
Organism Vibrio cholerae strain E7G

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPY10_RS15355 Protein ID WP_175247655.1
Coordinates 374863..375150 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HPY10_RS15350 Protein ID WP_175247654.1
Coordinates 374585..374866 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY10_RS15310 370048..370326 - 279 WP_175247649.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY10_RS15315 370323..370607 - 285 WP_175247650.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY10_RS15320 370606..370788 + 183 WP_072612510.1 DUF3265 domain-containing protein -
HPY10_RS15325 371771..372424 + 654 WP_175247651.1 hypothetical protein -
HPY10_RS15330 372378..372563 + 186 WP_175247725.1 DUF3265 domain-containing protein -
HPY10_RS15335 372550..373065 + 516 WP_076025898.1 MazG-related protein -
HPY10_RS15340 373273..374184 + 912 WP_175247652.1 hypothetical protein -
HPY10_RS15345 374196..374366 + 171 WP_175247653.1 hypothetical protein -
HPY10_RS15350 374585..374866 + 282 WP_175247654.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY10_RS15355 374863..375150 + 288 WP_175247655.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY10_RS15360 375308..375772 + 465 WP_076025888.1 ASCH domain-containing protein -
HPY10_RS15365 375837..375920 + 84 Protein_364 disulfide bond formation protein DsbD -
HPY10_RS15370 375918..376334 + 417 WP_069730442.1 DUF1311 domain-containing protein -
HPY10_RS15375 376652..376870 + 219 Protein_366 DUF645 family protein -
HPY10_RS15380 377066..377302 - 237 WP_000772130.1 RNA-binding protein -
HPY10_RS15385 377556..377825 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
HPY10_RS15390 377818..378096 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY10_RS15395 378850..379590 + 741 WP_162813548.1 PhzF family phenazine biosynthesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..527444 217390
- inside Integron - - 311218..527444 216226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-73)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11059.82 Da        Isoelectric Point: 6.0710

>T158081 WP_175247655.1 NZ_CP053823:374863-375150 [Vibrio cholerae]
MKVVWSPLALQKLGDVAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSFSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T158081 NZ_CP069565:1288424-1288786 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10347.90 Da        Isoelectric Point: 5.1548

>AT158081 WP_175247654.1 NZ_CP053823:374585-374866 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTGEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT158081 NZ_CP069565:1288257-1288427 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References