Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 370048..370607 Replicon chromosome
Accession NZ_CP053823
Organism Vibrio cholerae strain E7G

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPY10_RS15310 Protein ID WP_175247649.1
Coordinates 370048..370326 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HPY10_RS15315 Protein ID WP_175247650.1
Coordinates 370323..370607 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY10_RS15260 365514..365942 + 429 WP_000082746.1 hypothetical protein -
HPY10_RS15265 366446..366589 + 144 WP_175247724.1 DUF3265 domain-containing protein -
HPY10_RS15270 366600..366974 + 375 WP_045609619.1 hypothetical protein -
HPY10_RS15275 366961..367080 + 120 WP_155393806.1 DUF3265 domain-containing protein -
HPY10_RS15280 367107..367484 + 378 WP_103195776.1 hypothetical protein -
HPY10_RS15285 367618..368142 + 525 WP_175247645.1 GNAT family N-acetyltransferase -
HPY10_RS15290 368126..368317 + 192 WP_175247646.1 DUF3265 domain-containing protein -
HPY10_RS15295 368340..368624 + 285 WP_175247647.1 hypothetical protein -
HPY10_RS15300 368758..369075 + 318 WP_175247648.1 hypothetical protein -
HPY10_RS15305 369240..369911 + 672 WP_080930965.1 HAD-IA family hydrolase -
HPY10_RS15310 370048..370326 - 279 WP_175247649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY10_RS15315 370323..370607 - 285 WP_175247650.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY10_RS15320 370606..370788 + 183 WP_072612510.1 DUF3265 domain-containing protein -
HPY10_RS15325 371771..372424 + 654 WP_175247651.1 hypothetical protein -
HPY10_RS15330 372378..372563 + 186 WP_175247725.1 DUF3265 domain-containing protein -
HPY10_RS15335 372550..373065 + 516 WP_076025898.1 MazG-related protein -
HPY10_RS15340 373273..374184 + 912 WP_175247652.1 hypothetical protein -
HPY10_RS15345 374196..374366 + 171 WP_175247653.1 hypothetical protein -
HPY10_RS15350 374585..374866 + 282 WP_175247654.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY10_RS15355 374863..375150 + 288 WP_175247655.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..527444 217390
- inside Integron - - 311218..527444 216226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-74)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10982.69 Da        Isoelectric Point: 4.3697

>T158080 WP_175247649.1 NZ_CP053823:c370326-370048 [Vibrio cholerae]
MILWEEESLNDREKIFEFLHDFNPDAAERTDEIIEIKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGDFIRIM
RVLHQKQKFPVD

Download         Length: 279 bp

>T158080 NZ_CP053823:c370326-370048 [Vibrio cholerae]
ATGATTTTGTGGGAAGAAGAGTCTCTGAACGATCGTGAAAAGATCTTTGAGTTTCTTCATGATTTCAACCCTGACGCTGC
AGAAAGAACTGACGAGATCATCGAAATAAAAGTTGAAAACCTGTTAGAGCAACCTCTTATGGGGGTACAACGTGACGGAA
TCAGAGGGCGATTGCTCATAATTCCTGAAATATCGATGATCGTATCCTATTGGGTCGACGGTGACTTTATTCGCATAATG
CGTGTACTACACCAAAAGCAAAAGTTCCCGGTGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10889.28 Da        Isoelectric Point: 9.1896

>AT158080 WP_175247650.1 NZ_CP053823:c370607-370323 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKAVFVNHESAKAR
MAEHKAKIRNRGKL

Download         Length: 285 bp

>AT158080 NZ_CP053823:c370607-370323 [Vibrio cholerae]
ATGGACACTAGAATTCAGTTTCGTGTTGATGAAGAAACTAAACGACTAGCTCAACAAATGGCTGAAAGCCAAGGCAGAAC
ATTGAGTGATGCTTGCCGAGAATTGACTGAGCAACTAGCAGAACAACAGAGAAAGACCTTATCTCACGATGCATGGTTAA
CTGAACAAGTAAATTTGGCTTTTGAGAAGTTCGATTCAGGAAAAGCCGTTTTTGTTAACCACGAATCAGCAAAAGCTCGT
ATGGCCGAGCACAAAGCCAAAATTCGCAACCGAGGCAAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References