Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 354256..354794 Replicon chromosome
Accession NZ_CP053823
Organism Vibrio cholerae strain E7G

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag HPY10_RS15180 Protein ID WP_000802136.1
Coordinates 354256..354555 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag HPY10_RS15185 Protein ID WP_001107719.1
Coordinates 354552..354794 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY10_RS15155 350301..350855 + 555 WP_175247638.1 hypothetical protein -
HPY10_RS15160 350852..351022 + 171 WP_175247723.1 DUF3265 domain-containing protein -
HPY10_RS15165 350998..351312 + 315 WP_000248692.1 DUF4144 domain-containing protein -
HPY10_RS15170 352196..352840 + 645 WP_043990331.1 hypothetical protein -
HPY10_RS15175 353080..353580 + 501 WP_175247639.1 hypothetical protein -
HPY10_RS15180 354256..354555 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY10_RS15185 354552..354794 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HPY10_RS15190 355468..355815 + 348 WP_175247640.1 hypothetical protein -
HPY10_RS15195 356107..356288 + 182 Protein_330 DUF645 family protein -
HPY10_RS15200 356505..357257 + 753 WP_000116045.1 SDR family oxidoreductase -
HPY10_RS15205 357486..357668 + 183 WP_095482486.1 DUF645 family protein -
HPY10_RS15210 357860..359041 - 1182 WP_175247641.1 DNA (cytosine-5-)-methyltransferase -
HPY10_RS15215 359041..359589 - 549 WP_175247642.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..527444 217390
- inside Integron - - 311218..527444 216226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T158079 WP_000802136.1 NZ_CP053823:c354555-354256 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T158079 NZ_CP069565:1211457-1211561 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT158079 WP_001107719.1 NZ_CP053823:c354794-354552 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT158079 NZ_CP069565:c1211720-1211556 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References