158077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 325585..326083 Replicon chromosome
Accession NZ_CP053823
Organism Vibrio cholerae strain E7G

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag HPY10_RS14935 Protein ID WP_000589156.1
Coordinates 325585..325851 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID D7HCY3
Locus tag HPY10_RS14940 Protein ID WP_000643600.1
Coordinates 325838..326083 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY10_RS14910 321735..321968 + 234 WP_010319470.1 DUF3709 domain-containing protein -
HPY10_RS14915 322247..322714 + 468 WP_101412260.1 DUF1643 domain-containing protein -
HPY10_RS14920 322876..324375 - 1500 WP_175246408.1 hypothetical protein -
HPY10_RS14925 324691..324843 + 153 WP_114774755.1 DUF645 family protein -
HPY10_RS14930 325253..325348 + 96 WP_001907607.1 DUF645 family protein -
HPY10_RS14935 325585..325851 + 267 WP_000589156.1 BrnT family toxin Toxin
HPY10_RS14940 325838..326083 + 246 WP_000643600.1 hypothetical protein Antitoxin
HPY10_RS14945 326264..326614 - 351 WP_001086649.1 hypothetical protein -
HPY10_RS14950 326621..327910 - 1290 WP_175246596.1 hypothetical protein -
HPY10_RS14955 328265..328390 + 126 WP_175246597.1 DUF3709 domain-containing protein -
HPY10_RS14960 328408..328668 + 261 WP_032473168.1 DUF3709 domain-containing protein -
HPY10_RS14965 328895..329121 + 227 Protein_284 hypothetical protein -
HPY10_RS14970 329243..329353 + 111 WP_095462449.1 DUF3265 domain-containing protein -
HPY10_RS14975 329513..329686 + 174 WP_175246437.1 DUF3709 domain-containing protein -
HPY10_RS14980 330021..330884 + 864 WP_175246436.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..527444 217390
- inside Integron - - 311218..527444 216226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T158077 WP_000589156.1 NZ_CP053823:325585-325851 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T158077 NZ_CP069565:919877-919984 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9446.71 Da        Isoelectric Point: 6.4832

>AT158077 WP_000643600.1 NZ_CP053823:325838-326083 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVVDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT158077 NZ_CP069565:c920061-920001 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB D7HCY3

References