Detailed information of TA system TA158076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 319265..319803
• Replicon: chromosome
• Accession: NZ_CP053823
• Organism: Vibrio cholerae strain E7G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HPY10_RS14895
• Protein ID: WP_000802134.1
• Coordinates: 319265..319564 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A271VK51
• Locus tag: HPY10_RS14900
• Protein ID: WP_001107720.1
• Coordinates: 319561..319803 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY10_RS14835	314630..314968	+	339	WP_175246331.1	hypothetical protein	-
HPY10_RS14840	315125..315403	-	279	WP_000578473.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
HPY10_RS14845	315400..315684	-	285	WP_000381186.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
HPY10_RS14850	315893..316168	+	276	WP_000436062.1	hypothetical protein	-
HPY10_RS14855	316348..316518	+	171	WP_001080654.1	hypothetical protein	-
HPY10_RS14860	316518..316919	+	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	-
HPY10_RS14865	316906..317055	+	150	WP_175247721.1	DUF3265 domain-containing protein	-
HPY10_RS14870	317042..317323	+	282	WP_084981660.1	DUF1289 domain-containing protein	-
HPY10_RS14875	317571..318371	+	801	WP_114763308.1	nucleotide-binding protein	-
HPY10_RS14880	318362..318478	+	117	WP_114763309.1	DUF3265 domain-containing protein	-
HPY10_RS14885	318569..318850	+	282	WP_000086649.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY10_RS14890	318847..319134	+	288	WP_000869999.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY10_RS14895	319265..319564	-	300	WP_000802134.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY10_RS14900	319561..319803	-	243	WP_001107720.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HPY10_RS14905	320515..320955	+	441	WP_095473997.1	hypothetical protein	-
HPY10_RS14910	321735..321968	+	234	WP_010319470.1	DUF3709 domain-containing protein	-
HPY10_RS14915	322247..322714	+	468	WP_101412260.1	DUF1643 domain-containing protein	-
HPY10_RS14920	322876..324375	-	1500	WP_175246408.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	310054..527444	217390
	-	inside	Integron	-	-	311218..527444	216226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11601.34 Da
• Isoelectric Point: 9.9232

>T158076 WP_000802134.1 NZ_CP053823:c319564-319265 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T158076 NZ_CP069565:888295-888561 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8950.82 Da
• Isoelectric Point: 4.1677

>AT158076 WP_001107720.1 NZ_CP053823:c319803-319561 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR

Nucleotide

• Length: 243 bp

>AT158076 NZ_CP069565:888038-888295 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A271VK51