Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 319265..319803 | Replicon | chromosome |
| Accession | NZ_CP053823 | ||
| Organism | Vibrio cholerae strain E7G | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | HPY10_RS14895 | Protein ID | WP_000802134.1 |
| Coordinates | 319265..319564 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A271VK51 |
| Locus tag | HPY10_RS14900 | Protein ID | WP_001107720.1 |
| Coordinates | 319561..319803 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY10_RS14835 | 314630..314968 | + | 339 | WP_175246331.1 | hypothetical protein | - |
| HPY10_RS14840 | 315125..315403 | - | 279 | WP_000578473.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| HPY10_RS14845 | 315400..315684 | - | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY10_RS14850 | 315893..316168 | + | 276 | WP_000436062.1 | hypothetical protein | - |
| HPY10_RS14855 | 316348..316518 | + | 171 | WP_001080654.1 | hypothetical protein | - |
| HPY10_RS14860 | 316518..316919 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| HPY10_RS14865 | 316906..317055 | + | 150 | WP_175247721.1 | DUF3265 domain-containing protein | - |
| HPY10_RS14870 | 317042..317323 | + | 282 | WP_084981660.1 | DUF1289 domain-containing protein | - |
| HPY10_RS14875 | 317571..318371 | + | 801 | WP_114763308.1 | nucleotide-binding protein | - |
| HPY10_RS14880 | 318362..318478 | + | 117 | WP_114763309.1 | DUF3265 domain-containing protein | - |
| HPY10_RS14885 | 318569..318850 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY10_RS14890 | 318847..319134 | + | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY10_RS14895 | 319265..319564 | - | 300 | WP_000802134.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY10_RS14900 | 319561..319803 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| HPY10_RS14905 | 320515..320955 | + | 441 | WP_095473997.1 | hypothetical protein | - |
| HPY10_RS14910 | 321735..321968 | + | 234 | WP_010319470.1 | DUF3709 domain-containing protein | - |
| HPY10_RS14915 | 322247..322714 | + | 468 | WP_101412260.1 | DUF1643 domain-containing protein | - |
| HPY10_RS14920 | 322876..324375 | - | 1500 | WP_175246408.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 310054..527444 | 217390 | |
| - | inside | Integron | - | - | 311218..527444 | 216226 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11601.34 Da Isoelectric Point: 9.9232
>T158076 WP_000802134.1 NZ_CP053823:c319564-319265 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T158076 NZ_CP069565:888295-888561 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8950.82 Da Isoelectric Point: 4.1677
>AT158076 WP_001107720.1 NZ_CP053823:c319803-319561 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT158076 NZ_CP069565:888038-888295 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|