Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 485810..486576 Replicon chromosome
Accession NZ_CP053821
Organism Vibrio cholerae strain SA10G

Toxin (Protein)


Gene name - Uniprot ID A0A233HKB4
Locus tag HPY11_RS16300 Protein ID WP_000982256.1
Coordinates 485810..486307 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0Q0PQR2
Locus tag HPY11_RS16305 Protein ID WP_000246255.1
Coordinates 486304..486576 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY11_RS16260 481281..481553 - 273 WP_001915058.1 DUF1778 domain-containing protein -
HPY11_RS16265 481784..482299 + 516 WP_114721773.1 lipocalin family protein -
HPY11_RS16270 482953..483210 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY11_RS16275 483198..483500 + 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY11_RS16280 483655..483972 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY11_RS16285 483991..484233 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY11_RS16290 484628..485017 + 390 WP_175242351.1 VOC family protein -
HPY11_RS16295 485212..485535 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY11_RS16300 485810..486307 - 498 WP_000982256.1 GNAT family N-acetyltransferase Toxin
HPY11_RS16305 486304..486576 - 273 WP_000246255.1 DUF1778 domain-containing protein Antitoxin
HPY11_RS16310 486807..487283 + 477 WP_001047188.1 GNAT family N-acetyltransferase -
HPY11_RS16315 487527..488000 - 474 WP_000034755.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
HPY11_RS16320 488222..488836 + 615 WP_175246457.1 OmpA family protein -
HPY11_RS16325 489070..490632 + 1563 WP_175246458.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 310496..487283 176787
- inside Integron - - 311660..487283 175623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18539.23 Da        Isoelectric Point: 8.7753

>T158071 WP_000982256.1 NZ_CP053821:c486307-485810 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T158071 NZ_CP069560:c40922-40764 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9713.24 Da        Isoelectric Point: 6.2988

>AT158071 WP_000246255.1 NZ_CP053821:c486576-486304 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT158071 NZ_CP069560:c41006-40966 [Escherichia coli]
TTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A233HKB4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0PQR2

References