Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 483655..484233 | Replicon | chromosome |
| Accession | NZ_CP053821 | ||
| Organism | Vibrio cholerae strain SA10G | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | HPY11_RS16280 | Protein ID | WP_001180243.1 |
| Coordinates | 483655..483972 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | HPY11_RS16285 | Protein ID | WP_001961623.1 |
| Coordinates | 483991..484233 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY11_RS16240 | 479069..479524 | + | 456 | WP_095457989.1 | GNAT family N-acetyltransferase | - |
| HPY11_RS16245 | 479581..479673 | + | 93 | WP_175246454.1 | acetyltransferase | - |
| HPY11_RS16250 | 479670..480338 | + | 669 | WP_175246455.1 | hypothetical protein | - |
| HPY11_RS16255 | 480787..481284 | - | 498 | WP_175246456.1 | GNAT family N-acetyltransferase | - |
| HPY11_RS16260 | 481281..481553 | - | 273 | WP_001915058.1 | DUF1778 domain-containing protein | - |
| HPY11_RS16265 | 481784..482299 | + | 516 | WP_114721773.1 | lipocalin family protein | - |
| HPY11_RS16270 | 482953..483210 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY11_RS16275 | 483198..483500 | + | 303 | WP_000229322.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY11_RS16280 | 483655..483972 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY11_RS16285 | 483991..484233 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY11_RS16290 | 484628..485017 | + | 390 | WP_175242351.1 | VOC family protein | - |
| HPY11_RS16295 | 485212..485535 | + | 324 | WP_080299109.1 | DUF3709 domain-containing protein | - |
| HPY11_RS16300 | 485810..486307 | - | 498 | WP_000982256.1 | GNAT family N-acetyltransferase | - |
| HPY11_RS16305 | 486304..486576 | - | 273 | WP_000246255.1 | DUF1778 domain-containing protein | - |
| HPY11_RS16310 | 486807..487283 | + | 477 | WP_001047188.1 | GNAT family N-acetyltransferase | - |
| HPY11_RS16315 | 487527..488000 | - | 474 | WP_000034755.1 | FKBP-type peptidyl-prolyl cis-trans isomerase | - |
| HPY11_RS16320 | 488222..488836 | + | 615 | WP_175246457.1 | OmpA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 310496..487283 | 176787 | |
| - | inside | Integron | - | - | 311660..487283 | 175623 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T158070 WP_001180243.1 NZ_CP053821:c483972-483655 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T158070 NZ_CP069560:4549-4929 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8931.22 Da Isoelectric Point: 5.6630
>AT158070 WP_001961623.1 NZ_CP053821:c484233-483991 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL
Download Length: 243 bp
>AT158070 NZ_CP069560:4328-4549 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|