Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 482953..483500 Replicon chromosome
Accession NZ_CP053821
Organism Vibrio cholerae strain SA10G

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0PYS1
Locus tag HPY11_RS16275 Protein ID WP_000229322.1
Coordinates 483198..483500 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag HPY11_RS16270 Protein ID WP_000861987.1
Coordinates 482953..483210 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY11_RS16230 477998..478234 + 237 WP_081447723.1 DUF3709 domain-containing protein -
HPY11_RS16235 478514..478939 + 426 WP_001287986.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
HPY11_RS16240 479069..479524 + 456 WP_095457989.1 GNAT family N-acetyltransferase -
HPY11_RS16245 479581..479673 + 93 WP_175246454.1 acetyltransferase -
HPY11_RS16250 479670..480338 + 669 WP_175246455.1 hypothetical protein -
HPY11_RS16255 480787..481284 - 498 WP_175246456.1 GNAT family N-acetyltransferase -
HPY11_RS16260 481281..481553 - 273 WP_001915058.1 DUF1778 domain-containing protein -
HPY11_RS16265 481784..482299 + 516 WP_114721773.1 lipocalin family protein -
HPY11_RS16270 482953..483210 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY11_RS16275 483198..483500 + 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY11_RS16280 483655..483972 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY11_RS16285 483991..484233 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY11_RS16290 484628..485017 + 390 WP_175242351.1 VOC family protein -
HPY11_RS16295 485212..485535 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY11_RS16300 485810..486307 - 498 WP_000982256.1 GNAT family N-acetyltransferase -
HPY11_RS16305 486304..486576 - 273 WP_000246255.1 DUF1778 domain-containing protein -
HPY11_RS16310 486807..487283 + 477 WP_001047188.1 GNAT family N-acetyltransferase -
HPY11_RS16315 487527..488000 - 474 WP_000034755.1 FKBP-type peptidyl-prolyl cis-trans isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 310496..487283 176787
- inside Integron - - 311660..487283 175623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11737.67 Da        Isoelectric Point: 5.1972

>T158069 WP_000229322.1 NZ_CP053821:483198-483500 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T158069 NZ_CP069559:c4852041-4851868 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT158069 WP_000861987.1 NZ_CP053821:482953-483210 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT158069 NZ_CP069559:c4852365-4852069 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PYS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References