Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 480787..481553 Replicon chromosome
Accession NZ_CP053821
Organism Vibrio cholerae strain SA10G

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY11_RS16255 Protein ID WP_175246456.1
Coordinates 480787..481284 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY11_RS16260 Protein ID WP_001915058.1
Coordinates 481281..481553 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY11_RS16215 476451..476903 - 453 WP_000908576.1 hypothetical protein -
HPY11_RS16220 477343..477729 + 387 WP_123011595.1 NUDIX hydrolase -
HPY11_RS16225 477786..477980 + 195 WP_175246453.1 DUF3709 domain-containing protein -
HPY11_RS16230 477998..478234 + 237 WP_081447723.1 DUF3709 domain-containing protein -
HPY11_RS16235 478514..478939 + 426 WP_001287986.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
HPY11_RS16240 479069..479524 + 456 WP_095457989.1 GNAT family N-acetyltransferase -
HPY11_RS16245 479581..479673 + 93 WP_175246454.1 acetyltransferase -
HPY11_RS16250 479670..480338 + 669 WP_175246455.1 hypothetical protein -
HPY11_RS16255 480787..481284 - 498 WP_175246456.1 GNAT family N-acetyltransferase Toxin
HPY11_RS16260 481281..481553 - 273 WP_001915058.1 DUF1778 domain-containing protein Antitoxin
HPY11_RS16265 481784..482299 + 516 WP_114721773.1 lipocalin family protein -
HPY11_RS16270 482953..483210 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY11_RS16275 483198..483500 + 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY11_RS16280 483655..483972 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY11_RS16285 483991..484233 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY11_RS16290 484628..485017 + 390 WP_175242351.1 VOC family protein -
HPY11_RS16295 485212..485535 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY11_RS16300 485810..486307 - 498 WP_000982256.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 310496..487283 176787
- inside Integron - - 311660..487283 175623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18534.25 Da        Isoelectric Point: 8.7729

>T158068 WP_175246456.1 NZ_CP053821:c481284-480787 [Vibrio cholerae]
MMNTVLLEKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYEHYGFKAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T158068 NZ_CP069559:4840267-4840644 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACCCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9655.16 Da        Isoelectric Point: 6.2988

>AT158068 WP_001915058.1 NZ_CP053821:c481553-481281 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT158068 NZ_CP069559:4839809-4840177 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCACGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References