Detailed information of TA system TA158066

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 454961..455539
• Replicon: chromosome
• Accession: NZ_CP053821
• Organism: Vibrio cholerae strain SA10G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: O68848
• Locus tag: HPY11_RS16045
• Protein ID: WP_001180243.1
• Coordinates: 454961..455278 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HPY11_RS16050
• Protein ID: WP_001961623.1
• Coordinates: 455297..455539 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY11_RS16015	450055..450192	+	138	WP_175246445.1	DUF3265 domain-containing protein	-
HPY11_RS16020	450229..450930	+	702	WP_001175917.1	hypothetical protein	-
HPY11_RS16025	451168..452571	+	1404	WP_175246446.1	AAA family ATPase	-
HPY11_RS16030	452564..453115	+	552	WP_175246447.1	hypothetical protein	-
HPY11_RS16035	453428..453609	+	182	Protein_489	DUF645 family protein	-
HPY11_RS16040	453822..454826	+	1005	WP_000964932.1	LD-carboxypeptidase	-
HPY11_RS16045	454961..455278	-	318	WP_001180243.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY11_RS16050	455297..455539	-	243	WP_001961623.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY11_RS16055	456001..456111	+	111	WP_076025930.1	DUF645 family protein	-
HPY11_RS16060	456262..456996	+	735	WP_114716399.1	hypothetical protein	-
HPY11_RS16065	457160..457900	+	741	WP_162813548.1	PhzF family phenazine biosynthesis protein	-
HPY11_RS16070	458041..458616	+	576	WP_000199096.1	class I SAM-dependent methyltransferase	-
HPY11_RS16075	458791..459123	+	333	WP_000843587.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY11_RS16080	459110..459424	+	315	WP_000071008.1	DNA-binding transcriptional regulator	-
HPY11_RS16085	459421..459531	+	111	WP_080342631.1	DUF3265 domain-containing protein	-
HPY11_RS16090	459539..459856	-	318	WP_000077453.1	CcdB family protein	-
HPY11_RS16095	459856..460101	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	310496..487283	176787
	-	inside	Integron	-	-	311660..487283	175623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12158.97 Da
• Isoelectric Point: 9.7495

>T158066 WP_001180243.1 NZ_CP053821:c455278-454961 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T158066 NZ_CP069559:4536270-4536608 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAACCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAGCAAAACGCCACGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8931.22 Da
• Isoelectric Point: 5.6630

>AT158066 WP_001961623.1 NZ_CP053821:c455539-455297 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT158066 NZ_CP069559:c4536275-4536199 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0K9UJR8