Detailed information of TA system TA158062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 420616..421175
• Replicon: chromosome
• Accession: NZ_CP053821
• Organism: Vibrio cholerae strain SA10G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D2YI11
• Locus tag: HPY11_RS15770
• Protein ID: WP_000578473.1
• Coordinates: 420616..420894 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY11_RS15775
• Protein ID: WP_000381186.1
• Coordinates: 420891..421175 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY11_RS15715	416036..416132	+	97	Protein_425	DUF645 family protein	-
HPY11_RS15720	416488..416670	+	183	WP_071170650.1	DUF645 family protein	-
HPY11_RS15725	416876..417214	+	339	WP_175246331.1	hypothetical protein	-
HPY11_RS15730	417369..417734	+	366	WP_069730855.1	hypothetical protein	-
HPY11_RS15735	417880..418680	+	801	WP_114763308.1	nucleotide-binding protein	-
HPY11_RS15740	418671..418787	+	117	WP_114763309.1	DUF3265 domain-containing protein	-
HPY11_RS15745	418827..419102	+	276	WP_000436062.1	hypothetical protein	-
HPY11_RS15750	419282..419452	+	171	WP_001080654.1	hypothetical protein	-
HPY11_RS15755	419452..419853	+	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	-
HPY11_RS15760	419840..420013	+	174	WP_175246605.1	DUF3265 domain-containing protein	-
HPY11_RS15765	419988..420476	+	489	WP_044128169.1	GNAT family N-acetyltransferase	-
HPY11_RS15770	420616..420894	-	279	WP_000578473.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPY11_RS15775	420891..421175	-	285	WP_000381186.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPY11_RS15780	421985..422992	+	1008	WP_175246433.1	hypothetical protein	-
HPY11_RS15785	423062..423181	+	120	WP_114780049.1	acetyltransferase	-
HPY11_RS15790	423122..423439	-	318	WP_148532547.1	CcdB family protein	-
HPY11_RS15795	423439..423684	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY11_RS15800	424039..424182	+	144	Protein_442	DUF645 family protein	-
HPY11_RS15805	424346..424981	+	636	WP_175246434.1	DUF2807 domain-containing protein	-
HPY11_RS15810	425140..425616	+	477	WP_175246430.1	DM13 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	310496..487283	176787
	-	inside	Integron	-	-	311660..487283	175623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10868.59 Da
• Isoelectric Point: 4.6794

>T158062 WP_000578473.1 NZ_CP053821:c420894-420616 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T158062 NZ_CP069559:3962439-3962657 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10915.28 Da
• Isoelectric Point: 8.0775

>AT158062 WP_000381186.1 NZ_CP053821:c421175-420891 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT158062 NZ_CP069559:3962039-3962413 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: D2YI11