Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
| Location | 419282..419853 | Replicon | chromosome |
| Accession | NZ_CP053821 | ||
| Organism | Vibrio cholerae strain SA10G | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9KMA2 |
| Locus tag | HPY11_RS15755 | Protein ID | WP_000351248.1 |
| Coordinates | 419452..419853 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q8GNG3 |
| Locus tag | HPY11_RS15750 | Protein ID | WP_001080654.1 |
| Coordinates | 419282..419452 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY11_RS15715 | 416036..416132 | + | 97 | Protein_425 | DUF645 family protein | - |
| HPY11_RS15720 | 416488..416670 | + | 183 | WP_071170650.1 | DUF645 family protein | - |
| HPY11_RS15725 | 416876..417214 | + | 339 | WP_175246331.1 | hypothetical protein | - |
| HPY11_RS15730 | 417369..417734 | + | 366 | WP_069730855.1 | hypothetical protein | - |
| HPY11_RS15735 | 417880..418680 | + | 801 | WP_114763308.1 | nucleotide-binding protein | - |
| HPY11_RS15740 | 418671..418787 | + | 117 | WP_114763309.1 | DUF3265 domain-containing protein | - |
| HPY11_RS15745 | 418827..419102 | + | 276 | WP_000436062.1 | hypothetical protein | - |
| HPY11_RS15750 | 419282..419452 | + | 171 | WP_001080654.1 | hypothetical protein | Antitoxin |
| HPY11_RS15755 | 419452..419853 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| HPY11_RS15760 | 419840..420013 | + | 174 | WP_175246605.1 | DUF3265 domain-containing protein | - |
| HPY11_RS15765 | 419988..420476 | + | 489 | WP_044128169.1 | GNAT family N-acetyltransferase | - |
| HPY11_RS15770 | 420616..420894 | - | 279 | WP_000578473.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| HPY11_RS15775 | 420891..421175 | - | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY11_RS15780 | 421985..422992 | + | 1008 | WP_175246433.1 | hypothetical protein | - |
| HPY11_RS15785 | 423062..423181 | + | 120 | WP_114780049.1 | acetyltransferase | - |
| HPY11_RS15790 | 423122..423439 | - | 318 | WP_148532547.1 | CcdB family protein | - |
| HPY11_RS15795 | 423439..423684 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| HPY11_RS15800 | 424039..424182 | + | 144 | Protein_442 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 310496..487283 | 176787 | |
| - | inside | Integron | - | - | 311660..487283 | 175623 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14608.71 Da Isoelectric Point: 4.0128
>T158061 WP_000351248.1 NZ_CP053821:419452-419853 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T158061 NZ_CP069559:c3352873-3352499 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATATGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATATGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6287.35 Da Isoelectric Point: 10.7274
>AT158061 WP_001080654.1 NZ_CP053821:419282-419452 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT158061 NZ_CP069559:c3353294-3352920 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0PN34 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SJJ1 |