Detailed information of TA system TA158060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 402567..403114
• Replicon: chromosome
• Accession: NZ_CP053821
• Organism: Vibrio cholerae strain SA10G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0Q0PYS1
• Locus tag: HPY11_RS15610
• Protein ID: WP_000229322.1
• Coordinates: 402812..403114 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: HPY11_RS15605
• Protein ID: WP_000861987.1
• Coordinates: 402567..402824 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY11_RS15560	397916..398419	+	504	WP_001158952.1	DinB family protein	-
HPY11_RS15565	398786..398895	+	110	Protein_395	DUF645 family protein	-
HPY11_RS15570	399097..399474	+	378	WP_055028395.1	hypothetical protein	-
HPY11_RS15575	399476..399766	+	291	WP_055028394.1	hypothetical protein	-
HPY11_RS15580	399696..399896	+	201	WP_175246426.1	DUF3265 domain-containing protein	-
HPY11_RS15585	399926..400381	+	456	WP_000432865.1	hypothetical protein	-
HPY11_RS15590	400657..401238	+	582	WP_175246604.1	hypothetical protein	-
HPY11_RS15595	401716..401826	+	111	WP_086017781.1	DUF3265 domain-containing protein	-
HPY11_RS15600	401853..402368	+	516	WP_114721773.1	lipocalin family protein	-
HPY11_RS15605	402567..402824	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY11_RS15610	402812..403114	+	303	WP_000229322.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY11_RS15615	403190..403384	+	195	WP_175246427.1	DUF3709 domain-containing protein	-
HPY11_RS15620	403378..403626	+	249	WP_082069824.1	DUF3709 domain-containing protein	-
HPY11_RS15625	404001..404426	+	426	WP_175246428.1	hypothetical protein	-
HPY11_RS15630	404604..405374	+	771	WP_175246429.1	alpha/beta hydrolase	-
HPY11_RS15635	405526..405939	+	414	WP_055064865.1	NUDIX domain-containing protein	-
HPY11_RS15640	406081..406518	+	438	WP_172779930.1	NUDIX pyrophosphatase	-
HPY11_RS15645	407000..407110	+	111	WP_175246598.1	DUF3265 domain-containing protein	-
HPY11_RS15650	407145..407621	+	477	WP_175246430.1	DM13 domain-containing protein	-
HPY11_RS15655	407756..408073	+	318	WP_175246431.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	310496..487283	176787
	-	inside	Integron	-	-	311660..487283	175623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11737.67 Da
• Isoelectric Point: 5.1972

>T158060 WP_000229322.1 NZ_CP053821:402812-403114 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T158060 NZ_CP069559:3145161-3145268 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT158060 WP_000861987.1 NZ_CP053821:402567-402824 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT158060 NZ_CP069559:c3145108-3145047 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A0Q0PYS1

Antitoxin

• AlphaFold DB: A0A1T4SLM9