Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 392048..392613 Replicon chromosome
Accession NZ_CP053821
Organism Vibrio cholerae strain SA10G

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag HPY11_RS15500 Protein ID WP_000869999.1
Coordinates 392326..392613 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag HPY11_RS15495 Protein ID WP_000086649.1
Coordinates 392048..392329 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY11_RS15455 387300..387389 + 90 Protein_373 GNAT family N-acetyltransferase -
HPY11_RS15460 387378..387803 + 426 WP_069648835.1 GNAT family N-acetyltransferase -
HPY11_RS15465 387941..388282 + 342 WP_042988175.1 hypothetical protein -
HPY11_RS15470 388439..388879 + 441 WP_095473997.1 hypothetical protein -
HPY11_RS15475 389033..389392 + 360 WP_175246420.1 VOC family protein -
HPY11_RS15480 389553..391382 + 1830 WP_097353650.1 AAA family ATPase -
HPY11_RS15485 391499..391725 + 227 Protein_379 hypothetical protein -
HPY11_RS15490 391847..391957 + 111 WP_095462449.1 DUF3265 domain-containing protein -
HPY11_RS15495 392048..392329 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY11_RS15500 392326..392613 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY11_RS15505 392840..393106 + 267 WP_175246421.1 hypothetical protein -
HPY11_RS15510 393281..393676 + 396 WP_175246422.1 DUF3465 domain-containing protein -
HPY11_RS15515 393803..393964 + 162 WP_175246423.1 hypothetical protein -
HPY11_RS15520 394153..394263 + 111 WP_175246602.1 DUF3265 domain-containing protein -
HPY11_RS15525 394307..394666 + 360 WP_076025909.1 VOC family protein -
HPY11_RS15530 394835..395311 + 477 WP_175246603.1 DUF2059 domain-containing protein -
HPY11_RS15535 395511..396305 - 795 WP_175246424.1 NYN domain-containing protein -
HPY11_RS15540 396392..396547 + 156 WP_175246425.1 DUF3265 domain-containing protein -
HPY11_RS15545 396799..396912 + 114 Protein_391 DUF645 family protein -
HPY11_RS15550 397171..397452 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 310496..487283 176787
- inside Integron - - 311660..487283 175623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T158058 WP_000869999.1 NZ_CP053821:392326-392613 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T158058 NZ_CP069559:2839200-2840522 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGAGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAATGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT158058 WP_000086649.1 NZ_CP053821:392048-392329 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT158058 NZ_CP069559:2838934-2839200 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAATGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTAACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCAAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References