Detailed information of TA system TA158057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 378508..379067
• Replicon: chromosome
• Accession: NZ_CP053821
• Organism: Vibrio cholerae strain SA10G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY11_RS15375
• Protein ID: WP_175246416.1
• Coordinates: 378508..378786 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: HPY11_RS15380
• Protein ID: WP_000381183.1
• Coordinates: 378783..379067 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY11_RS15335	374120..374545	+	426	WP_002045007.1	GNAT family N-acetyltransferase	-
HPY11_RS15340	374739..375452	+	714	WP_000123660.1	Fic family protein	-
HPY11_RS15345	375748..375837	+	90	WP_001905720.1	DUF645 family protein	-
HPY11_RS15350	375837..375929	+	93	Protein_352	DUF645 family protein	-
HPY11_RS15355	376145..376540	+	396	WP_175246415.1	DUF3465 domain-containing protein	-
HPY11_RS15360	376641..377318	+	678	WP_175246600.1	FMN-binding negative transcriptional regulator	-
HPY11_RS15365	377450..377731	+	282	WP_148495578.1	DUF1289 domain-containing protein	-
HPY11_RS15370	378016..378252	-	237	WP_000772130.1	RNA-binding protein	-
HPY11_RS15375	378508..378786	-	279	WP_175246416.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY11_RS15380	378783..379067	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPY11_RS15385	379244..379561	-	318	WP_000077453.1	CcdB family protein	-
HPY11_RS15390	379561..379806	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY11_RS15395	380334..380444	+	111	WP_175246601.1	DUF3265 domain-containing protein	-
HPY11_RS15400	380454..380942	+	489	WP_057558160.1	dual specificity protein phosphatase family protein	-
HPY11_RS15405	381289..381408	+	120	WP_175246417.1	DUF645 family protein	-
HPY11_RS15410	381739..382014	+	276	WP_113629420.1	hypothetical protein	-
HPY11_RS15415	382020..382505	+	486	WP_113629421.1	hypothetical protein	-
HPY11_RS15420	382822..383754	+	933	WP_046126168.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	310496..487283	176787
	-	inside	Integron	-	-	311660..487283	175623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10795.53 Da
• Isoelectric Point: 4.5216

>T158057 WP_175246416.1 NZ_CP053821:c378786-378508 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIIGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T158057 NZ_CP069559:2552202-2552304 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT158057 WP_000381183.1 NZ_CP053821:c379067-378783 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT158057 NZ_CP069559:c2552342-2552074 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A067BL33