Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 362735..363300 Replicon chromosome
Accession NZ_CP053821
Organism Vibrio cholerae strain SA10G

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag HPY11_RS15245 Protein ID WP_000869999.1
Coordinates 363013..363300 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag HPY11_RS15240 Protein ID WP_000086649.1
Coordinates 362735..363016 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY11_RS15210 358338..358571 + 234 WP_010319470.1 DUF3709 domain-containing protein -
HPY11_RS15215 359008..359179 + 172 Protein_325 DUF645 family protein -
HPY11_RS15220 359378..359974 + 597 WP_175246409.1 glutathione S-transferase family protein -
HPY11_RS15225 360573..361124 + 552 WP_000821928.1 hypothetical protein -
HPY11_RS15230 361308..361892 + 585 WP_175246410.1 hypothetical protein -
HPY11_RS15235 362169..362402 + 234 WP_010319470.1 DUF3709 domain-containing protein -
HPY11_RS15240 362735..363016 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY11_RS15245 363013..363300 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY11_RS15250 363433..363714 + 282 WP_084981660.1 DUF1289 domain-containing protein -
HPY11_RS15255 363979..364419 + 441 WP_095473997.1 hypothetical protein -
HPY11_RS15260 364652..365542 + 891 WP_175246411.1 hypothetical protein -
HPY11_RS15265 365792..366028 + 237 WP_161803464.1 DUF645 family protein -
HPY11_RS15270 366143..366538 + 396 WP_175246412.1 DUF4144 domain-containing protein -
HPY11_RS15275 366850..367029 + 180 WP_148524399.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 310496..487283 176787
- inside Integron - - 311660..487283 175623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T158056 WP_000869999.1 NZ_CP053821:363013-363300 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T158056 NZ_CP069559:2283615-2283869 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGAAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT158056 WP_000086649.1 NZ_CP053821:362735-363016 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT158056 NZ_CP069559:2283367-2283618 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References