Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 506938..507516 | Replicon | chromosome |
| Accession | NZ_CP053817 | ||
| Organism | Vibrio cholerae strain SA7G | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | HPY17_RS16480 | Protein ID | WP_001180243.1 |
| Coordinates | 506938..507255 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | HPY17_RS16485 | Protein ID | WP_001961623.1 |
| Coordinates | 507274..507516 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY17_RS16440 | 502352..502807 | + | 456 | WP_095457989.1 | GNAT family N-acetyltransferase | - |
| HPY17_RS16445 | 502864..502956 | + | 93 | WP_175246454.1 | acetyltransferase | - |
| HPY17_RS16450 | 502953..503621 | + | 669 | WP_175246455.1 | hypothetical protein | - |
| HPY17_RS16455 | 504070..504567 | - | 498 | WP_175246456.1 | GNAT family N-acetyltransferase | - |
| HPY17_RS16460 | 504564..504836 | - | 273 | WP_001915058.1 | DUF1778 domain-containing protein | - |
| HPY17_RS16465 | 505067..505582 | + | 516 | WP_114721773.1 | lipocalin family protein | - |
| HPY17_RS16470 | 506236..506493 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY17_RS16475 | 506481..506783 | + | 303 | WP_000229322.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY17_RS16480 | 506938..507255 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY17_RS16485 | 507274..507516 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY17_RS16490 | 507911..508300 | + | 390 | WP_175242351.1 | VOC family protein | - |
| HPY17_RS16495 | 508495..508818 | + | 324 | WP_080299109.1 | DUF3709 domain-containing protein | - |
| HPY17_RS16500 | 509093..509590 | - | 498 | WP_000982256.1 | GNAT family N-acetyltransferase | - |
| HPY17_RS16505 | 509587..509859 | - | 273 | WP_000246255.1 | DUF1778 domain-containing protein | - |
| HPY17_RS16510 | 510090..510566 | + | 477 | WP_001047188.1 | GNAT family N-acetyltransferase | - |
| HPY17_RS16515 | 510810..511283 | - | 474 | WP_000034755.1 | FKBP-type peptidyl-prolyl cis-trans isomerase | - |
| HPY17_RS16520 | 511505..512119 | + | 615 | WP_175246457.1 | OmpA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 310054..510566 | 200512 | |
| - | inside | Integron | - | - | 311218..510566 | 199348 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T158049 WP_001180243.1 NZ_CP053817:c507255-506938 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T158049 NZ_CP069559:c405574-405197 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8931.22 Da Isoelectric Point: 5.6630
>AT158049 WP_001961623.1 NZ_CP053817:c507516-507274 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL
Download Length: 243 bp
>AT158049 NZ_CP069559:c406032-405664 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCAAAATGAAAAATTAA
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCAAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|