Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 506236..506783 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0PYS1
Locus tag HPY17_RS16475 Protein ID WP_000229322.1
Coordinates 506481..506783 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag HPY17_RS16470 Protein ID WP_000861987.1
Coordinates 506236..506493 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS16430 501281..501517 + 237 WP_081447723.1 DUF3709 domain-containing protein -
HPY17_RS16435 501797..502222 + 426 WP_061051384.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
HPY17_RS16440 502352..502807 + 456 WP_095457989.1 GNAT family N-acetyltransferase -
HPY17_RS16445 502864..502956 + 93 WP_175246454.1 acetyltransferase -
HPY17_RS16450 502953..503621 + 669 WP_175246455.1 hypothetical protein -
HPY17_RS16455 504070..504567 - 498 WP_175246456.1 GNAT family N-acetyltransferase -
HPY17_RS16460 504564..504836 - 273 WP_001915058.1 DUF1778 domain-containing protein -
HPY17_RS16465 505067..505582 + 516 WP_114721773.1 lipocalin family protein -
HPY17_RS16470 506236..506493 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY17_RS16475 506481..506783 + 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY17_RS16480 506938..507255 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY17_RS16485 507274..507516 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY17_RS16490 507911..508300 + 390 WP_175242351.1 VOC family protein -
HPY17_RS16495 508495..508818 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY17_RS16500 509093..509590 - 498 WP_000982256.1 GNAT family N-acetyltransferase -
HPY17_RS16505 509587..509859 - 273 WP_000246255.1 DUF1778 domain-containing protein -
HPY17_RS16510 510090..510566 + 477 WP_001047188.1 GNAT family N-acetyltransferase -
HPY17_RS16515 510810..511283 - 474 WP_000034755.1 FKBP-type peptidyl-prolyl cis-trans isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11737.67 Da        Isoelectric Point: 5.1972

>T158048 WP_000229322.1 NZ_CP053817:506481-506783 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T158048 NZ_CP069558:1495962-1496816 [Streptococcus constellatus]
ATGAAAACATCGGAGCAGATAAAAGGAGCGATTAGGAACATATCTAAGAAAACAGGAGTTAATCCGAACTCTCTGCTTCA
GATGTGCTTATTCGAAGGAATACTTGAAAAACTCTCCAAATCAAAATATAGTGAGAATTTTATATTAAAAGGCGGACTTC
TTATATCCTCTCTTATCGGTGTTGATATGCGTAGTACAATGGACATGGATACCACGATTAGAGGCATTCCACTAAATGAA
GAGTCTATAACAAAAATCTTAAATGAAATATTAGCGATTGAAATTGATGCAGATATTGAATATAAGCTGATTAAATTATC
GCCAATAAGACAGGAAGATGTGTATGAAGATTTTTGTGCAAGCATATCCTGCATTTTTGGGAAAATAAATGCAATCTTAA
ATATAGATATAACGACAGGAGATGTTATTACTCCAAGAGAAATGAATTATTCCTATTCAAAAATCTTAGAAGAAGGTACA
ATACCGATTATGACCTATACCATAGAAACTATACTTGCTGAAAAATTTGAAACCATTTCAAGCAGAAATATTACCACAAC
AAGAGCAAGGGATTTCTATGATTTGTATATGATATACAGCATTTATAAAGATAAAATTGATAAAGACATATTAAGAAAAG
CAATAGAAAGAACGAGTAAATACAGAGGTTCTTTTGAAACAGCTTTACAGTATAAGGAAATAGTAGAGTTGTTCCGGGAA
AGTGAAACACCAAAAGAACTATGGAAAAAATACACACAGAATAACCCGTATGCTAAAGATGTTGATTTCTTAGATACTAT
ATCAATCTATGAAGAAATAGGTACTGTATTAAATGTGAATGATGATACTAAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT158048 WP_000861987.1 NZ_CP053817:506236-506493 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT158048 NZ_CP069558:1495366-1495965 [Streptococcus constellatus]
ATGAGTAAACGGGAACTCCTGCTAAAAAAAATAAAAGAAAATAATGGGATTATAACTACCAAAGAAGCCTTAAATCTTGG
TATTCATAAGGATATCCTAAAAGAATTAACCATAAAAGAAGAACTCGAAAAAATAGCCAACGGACTCTATGTACTTCCGG
ATGAGAATATCGATGAGTATCTTTATTTCTCATACAGAATACCCAAAGGTATTTTTTCTCACGAAACAGCAGCGTATTTA
CAAGGATTATCAACACGAATGCCCCTTGTTTATGTGATGACTGTAAAGGTAGGAGATAATGTCAGCAGAGTTAAGTCGGC
AAGAGATAATATTATTTTTAAGTATGTAAAAAAAGATTATTACGATATTGGGAAAATAACTATAACCAGTCCTTTTGGCA
GAGAAATATCAGTGTATGACAAAGAAAGAACCATACTTGATATTATCAAAGATAAGGACAGAATAGATGCACAAGTATTT
AGCGAAGCAATAAAATCTTACTTTGCAGGTAAGGAGAAAGATTTATTAAAACTGTCGAAATATGCTATTAAGATGAATAT
GGAGCAAGCTTTAAAACGATATACGGAGGTGCTGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PYS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References