Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 504070..504836 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY17_RS16455 Protein ID WP_175246456.1
Coordinates 504070..504567 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY17_RS16460 Protein ID WP_001915058.1
Coordinates 504564..504836 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS16415 499734..500186 - 453 WP_000908576.1 hypothetical protein -
HPY17_RS16420 500626..501012 + 387 WP_123011595.1 NUDIX hydrolase -
HPY17_RS16425 501069..501263 + 195 WP_175246453.1 DUF3709 domain-containing protein -
HPY17_RS16430 501281..501517 + 237 WP_081447723.1 DUF3709 domain-containing protein -
HPY17_RS16435 501797..502222 + 426 WP_061051384.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
HPY17_RS16440 502352..502807 + 456 WP_095457989.1 GNAT family N-acetyltransferase -
HPY17_RS16445 502864..502956 + 93 WP_175246454.1 acetyltransferase -
HPY17_RS16450 502953..503621 + 669 WP_175246455.1 hypothetical protein -
HPY17_RS16455 504070..504567 - 498 WP_175246456.1 GNAT family N-acetyltransferase Toxin
HPY17_RS16460 504564..504836 - 273 WP_001915058.1 DUF1778 domain-containing protein Antitoxin
HPY17_RS16465 505067..505582 + 516 WP_114721773.1 lipocalin family protein -
HPY17_RS16470 506236..506493 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY17_RS16475 506481..506783 + 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY17_RS16480 506938..507255 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY17_RS16485 507274..507516 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY17_RS16490 507911..508300 + 390 WP_175242351.1 VOC family protein -
HPY17_RS16495 508495..508818 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY17_RS16500 509093..509590 - 498 WP_000982256.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18534.25 Da        Isoelectric Point: 8.7729

>T158047 WP_175246456.1 NZ_CP053817:c504567-504070 [Vibrio cholerae]
MMNTVLLEKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYEHYGFKAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T158047 NZ_CP069558:c1013705-1013340 [Streptococcus constellatus]
GTGCATAATATCTATTTTTACAAGGATAAAAACGGTAATGAGCCTATTTTAGATTATATGCGAGAGCTTGCCAGTAAAAA
GGGAAAAGATAGTAGAATTAAACTCAATAAAATCAATGATTATATTGAGTTGTTAAGTCAACACGGAACACGCACAGGCG
AGCCATATATTAAGCATTTAGATGCTGAAATTTGGGAACTAAGACCATTAAGGGATAGAATTTTATTTGTTGCATGGATT
GATGGTAGCTTTGTTTTACTCCATCATTTCATGAAAAAGACACAGAAAACACCAAAAAGAGAGATTGAACAAGCTAAACG
TGAGTTAGCAGACTTAAAAGAAAGAGGTTTAGACAATGAAAAATAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9655.16 Da        Isoelectric Point: 6.2988

>AT158047 WP_001915058.1 NZ_CP053817:c504836-504564 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT158047 NZ_CP069558:c1013350-1013054 [Streptococcus constellatus]
ATGAAAAATAGTGCAATTGGTAGTAACTGGAAAGATGTAAGAGCTGAGTTATTCAGCAAAGAAGAAATTTTAGAAAGTGA
TATGCGTGTGGCTATCATGAGTGAGCTTATCGAGGCTAGGAATGAAAGGGGTATTAGTCAGAAAAAACTAGAGGAGCTGA
GTGGTGTTAGTCAGCCAGTCATAGCTAGAATGGAGACAGGAAAAACAAGCCCACAGCTTGATACCGTTTTAAAAGTATTA
GCAAGTCTTGGTAAGACGTTGGCTGTTGTACCCTTAGAGGGCGAACAGATAAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References