Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 478244..478822 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag HPY17_RS16245 Protein ID WP_001180243.1
Coordinates 478244..478561 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HPY17_RS16250 Protein ID WP_001961623.1
Coordinates 478580..478822 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS16215 473338..473475 + 138 WP_175246445.1 DUF3265 domain-containing protein -
HPY17_RS16220 473512..474213 + 702 WP_001175917.1 hypothetical protein -
HPY17_RS16225 474451..475854 + 1404 WP_175246446.1 AAA family ATPase -
HPY17_RS16230 475847..476398 + 552 WP_175246447.1 hypothetical protein -
HPY17_RS16235 476711..476892 + 182 Protein_538 DUF645 family protein -
HPY17_RS16240 477105..478109 + 1005 WP_000964932.1 LD-carboxypeptidase -
HPY17_RS16245 478244..478561 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY17_RS16250 478580..478822 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY17_RS16255 479284..479394 + 111 WP_076025930.1 DUF645 family protein -
HPY17_RS16260 479545..480279 + 735 WP_114716399.1 hypothetical protein -
HPY17_RS16265 480443..481183 + 741 WP_162813548.1 PhzF family phenazine biosynthesis protein -
HPY17_RS16270 481324..481899 + 576 WP_000199096.1 class I SAM-dependent methyltransferase -
HPY17_RS16275 482074..482406 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY17_RS16280 482393..482707 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
HPY17_RS16285 482704..482814 + 111 WP_080342631.1 DUF3265 domain-containing protein -
HPY17_RS16290 482822..483139 - 318 WP_000077453.1 CcdB family protein -
HPY17_RS16295 483139..483384 - 246 WP_001260801.1 type II toxin-antitoxin system CcdA family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T158045 WP_001180243.1 NZ_CP053817:c478561-478244 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T158045 NZ_CP069549:4430651-4430803 [Escherichia coli]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGTTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8931.22 Da        Isoelectric Point: 5.6630

>AT158045 WP_001961623.1 NZ_CP053817:c478822-478580 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Download         Length: 243 bp

>AT158045 NZ_CP069549:c4430609-4430557 [Escherichia coli]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure

References