Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 468953..469803 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY17_RS16170 Protein ID WP_175246444.1
Coordinates 469270..469803 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY17_RS16165 Protein ID WP_175247675.1
Coordinates 468953..469273 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS16130 464392..464769 + 378 WP_175246443.1 hypothetical protein -
HPY17_RS16135 464927..465352 + 426 WP_001887505.1 GNAT family N-acetyltransferase -
HPY17_RS16140 465409..466263 + 855 WP_116672171.1 aminoglycoside phosphotransferase family protein -
HPY17_RS16145 466423..466881 + 459 WP_114755989.1 hypothetical protein -
HPY17_RS16150 467298..467723 + 426 WP_000415750.1 hypothetical protein -
HPY17_RS16155 468071..468252 + 182 Protein_522 DUF645 family protein -
HPY17_RS16160 468744..468950 + 207 WP_175247674.1 DUF3265 domain-containing protein -
HPY17_RS16165 468953..469273 + 321 WP_175247675.1 DUF1778 domain-containing protein Antitoxin
HPY17_RS16170 469270..469803 + 534 WP_175246444.1 GNAT family N-acetyltransferase Toxin
HPY17_RS16175 470109..470291 + 183 WP_001933694.1 DUF645 family protein -
HPY17_RS16180 470440..471045 + 606 WP_175242423.1 suppressor of fused domain protein -
HPY17_RS16185 471050..471160 + 111 WP_080100071.1 DUF3265 domain-containing protein -
HPY17_RS16190 471201..471656 + 456 WP_000432865.1 hypothetical protein -
HPY17_RS16195 471833..472099 + 267 WP_000589156.1 BrnT family toxin -
HPY17_RS16200 472086..472331 + 246 WP_000643598.1 hypothetical protein -
HPY17_RS16205 472806..472916 + 111 WP_086017781.1 DUF3265 domain-containing protein -
HPY17_RS16210 472958..473368 + 411 WP_025613414.1 cytidine deaminase -
HPY17_RS16215 473338..473475 + 138 WP_175246445.1 DUF3265 domain-containing protein -
HPY17_RS16220 473512..474213 + 702 WP_001175917.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(22-98)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20196.56 Da        Isoelectric Point: 9.6050

>T158043 WP_175246444.1 NZ_CP053817:469270-469803 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKKFHGSGLGKVSLIRALKYLWEVNYHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T158043 NZ_CP069549:4287424-4287831 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11717.45 Da        Isoelectric Point: 4.9309

>AT158043 WP_175247675.1 NZ_CP053817:468953-469273 [Vibrio cholerae]
MAYNRSTDGMYPYAGGGMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 321 bp

>AT158043 NZ_CP069549:4287177-4287443 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References