Detailed information of TA system TA158042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 449751..450298
• Replicon: chromosome
• Accession: NZ_CP053817
• Organism: Vibrio cholerae strain SA7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY17_RS16025
• Protein ID: WP_071187828.1
• Coordinates: 449996..450298 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY17_RS16020
• Protein ID: WP_055031549.1
• Coordinates: 449751..450008 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY17_RS15975	444797..445804	+	1008	WP_175246433.1	hypothetical protein	-
HPY17_RS15980	445874..445993	+	120	WP_114780049.1	acetyltransferase	-
HPY17_RS15985	445934..446251	-	318	WP_148532547.1	CcdB family protein	-
HPY17_RS15990	446251..446496	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY17_RS15995	446851..446994	+	144	Protein_490	DUF645 family protein	-
HPY17_RS16000	447158..447793	+	636	WP_175246434.1	DUF2807 domain-containing protein	-
HPY17_RS16005	447952..448428	+	477	WP_175246430.1	DM13 domain-containing protein	-
HPY17_RS16010	448590..449015	+	426	WP_061051384.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
HPY17_RS16015	449174..449560	+	387	WP_123011595.1	NUDIX hydrolase	-
HPY17_RS16020	449751..450008	+	258	WP_055031549.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY17_RS16025	449996..450298	+	303	WP_071187828.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY17_RS16030	450616..451248	+	633	WP_175246435.1	FRG domain-containing protein	-
HPY17_RS16035	451391..452254	+	864	WP_175246436.1	hypothetical protein	-
HPY17_RS16040	452426..453178	+	753	WP_114720911.1	SDR family oxidoreductase	-
HPY17_RS16045	453455..453628	+	174	WP_175246437.1	DUF3709 domain-containing protein	-
HPY17_RS16050	453960..454808	+	849	WP_175246438.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	310054..510566	200512
	-	inside	Integron	-	-	311218..510566	199348

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11694.60 Da
• Isoelectric Point: 5.8741

>T158042 WP_071187828.1 NZ_CP053817:449996-450298 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELKHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T158042 NZ_CP069549:3560988-3561140 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGAGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAAATTGAAAGAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9619.14 Da
• Isoelectric Point: 7.3176

>AT158042 WP_055031549.1 NZ_CP053817:449751-450008 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT158042 NZ_CP069549:c3560931-3560883 [Escherichia coli]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG