Detailed information of TA system TA158041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 443428..443987
• Replicon: chromosome
• Accession: NZ_CP053817
• Organism: Vibrio cholerae strain SA7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D2YI11
• Locus tag: HPY17_RS15965
• Protein ID: WP_000578473.1
• Coordinates: 443428..443706 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY17_RS15970
• Protein ID: WP_000381186.1
• Coordinates: 443703..443987 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY17_RS15910	438848..438944	+	97	Protein_473	DUF645 family protein	-
HPY17_RS15915	439300..439482	+	183	WP_071170650.1	DUF645 family protein	-
HPY17_RS15920	439688..440026	+	339	WP_175246331.1	hypothetical protein	-
HPY17_RS15925	440181..440546	+	366	WP_069730855.1	hypothetical protein	-
HPY17_RS15930	440692..441492	+	801	WP_114763308.1	nucleotide-binding protein	-
HPY17_RS15935	441483..441599	+	117	WP_114763309.1	DUF3265 domain-containing protein	-
HPY17_RS15940	441639..441914	+	276	WP_000436062.1	hypothetical protein	-
HPY17_RS15945	442094..442264	+	171	WP_001080654.1	hypothetical protein	-
HPY17_RS15950	442264..442665	+	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	-
HPY17_RS15955	442652..442825	+	174	WP_175246605.1	DUF3265 domain-containing protein	-
HPY17_RS15960	442800..443288	+	489	WP_044128169.1	GNAT family N-acetyltransferase	-
HPY17_RS15965	443428..443706	-	279	WP_000578473.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPY17_RS15970	443703..443987	-	285	WP_000381186.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPY17_RS15975	444797..445804	+	1008	WP_175246433.1	hypothetical protein	-
HPY17_RS15980	445874..445993	+	120	WP_114780049.1	acetyltransferase	-
HPY17_RS15985	445934..446251	-	318	WP_148532547.1	CcdB family protein	-
HPY17_RS15990	446251..446496	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY17_RS15995	446851..446994	+	144	Protein_490	DUF645 family protein	-
HPY17_RS16000	447158..447793	+	636	WP_175246434.1	DUF2807 domain-containing protein	-
HPY17_RS16005	447952..448428	+	477	WP_175246430.1	DM13 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	310054..510566	200512
	-	inside	Integron	-	-	311218..510566	199348

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10868.59 Da
• Isoelectric Point: 4.6794

>T158041 WP_000578473.1 NZ_CP053817:c443706-443428 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T158041 NZ_CP069549:c3187365-3187054 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10915.28 Da
• Isoelectric Point: 8.0775

>AT158041 WP_000381186.1 NZ_CP053817:c443987-443703 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT158041 NZ_CP069549:c3187053-3186763 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGTACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Toxin

• AlphaFold DB: D2YI11