Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 430564..431111 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0PYS1
Locus tag HPY17_RS15850 Protein ID WP_000229322.1
Coordinates 430809..431111 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag HPY17_RS15845 Protein ID WP_000861987.1
Coordinates 430564..430821 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS15805 425682..425987 - 306 WP_024699541.1 helix-turn-helix domain-containing protein -
HPY17_RS15810 425996..426319 - 324 WP_024699542.1 hypothetical protein -
HPY17_RS15815 426744..426971 - 228 WP_024699543.1 hypothetical protein -
HPY17_RS15820 427349..427762 + 414 WP_175242843.1 VOC family protein -
HPY17_RS15825 427923..428378 + 456 WP_000432865.1 hypothetical protein -
HPY17_RS15830 428654..429235 + 582 WP_175246604.1 hypothetical protein -
HPY17_RS15835 429713..429823 + 111 WP_086017781.1 DUF3265 domain-containing protein -
HPY17_RS15840 429850..430365 + 516 WP_114721773.1 lipocalin family protein -
HPY17_RS15845 430564..430821 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY17_RS15850 430809..431111 + 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY17_RS15855 431187..431381 + 195 WP_175246427.1 DUF3709 domain-containing protein -
HPY17_RS15860 431375..431623 + 249 WP_082069824.1 DUF3709 domain-containing protein -
HPY17_RS15865 431998..432423 + 426 WP_033928096.1 hypothetical protein -
HPY17_RS15870 432601..433371 + 771 WP_175246429.1 alpha/beta hydrolase -
HPY17_RS15875 433523..433936 + 414 WP_055064865.1 NUDIX domain-containing protein -
HPY17_RS15880 434078..434515 + 438 WP_172779930.1 NUDIX pyrophosphatase -
HPY17_RS15885 434997..435107 + 111 WP_175246598.1 DUF3265 domain-containing protein -
HPY17_RS15890 435136..435642 + 507 WP_123011681.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11737.67 Da        Isoelectric Point: 5.1972

>T158039 WP_000229322.1 NZ_CP053817:430809-431111 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T158039 NZ_CP069549:c2773728-2773438 [Escherichia coli]
ATGAACTATGAGCTGACGTTTGATCCGCGGGCACTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGCGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTACGAAGACGCGGATAAACGACTGGATGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT158039 WP_000861987.1 NZ_CP053817:430564-430821 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT158039 NZ_CP069549:c2773960-2773718 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PYS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References