Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 413828..414393 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag HPY17_RS15685 Protein ID WP_000869999.1
Coordinates 414106..414393 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag HPY17_RS15680 Protein ID WP_000086649.1
Coordinates 413828..414109 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS15640 409080..409169 + 90 Protein_419 GNAT family N-acetyltransferase -
HPY17_RS15645 409158..409583 + 426 WP_069648835.1 GNAT family N-acetyltransferase -
HPY17_RS15650 409721..410062 + 342 WP_042988175.1 hypothetical protein -
HPY17_RS15655 410219..410659 + 441 WP_095473997.1 hypothetical protein -
HPY17_RS15660 410813..411172 + 360 WP_175246420.1 VOC family protein -
HPY17_RS15665 411333..413162 + 1830 WP_097353650.1 AAA family ATPase -
HPY17_RS15670 413279..413505 + 227 Protein_425 hypothetical protein -
HPY17_RS15675 413627..413737 + 111 WP_095462449.1 DUF3265 domain-containing protein -
HPY17_RS15680 413828..414109 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY17_RS15685 414106..414393 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY17_RS15690 414620..414886 + 267 WP_175246421.1 hypothetical protein -
HPY17_RS15695 415061..415456 + 396 WP_175246422.1 DUF3465 domain-containing protein -
HPY17_RS15700 415583..415744 + 162 WP_175246423.1 hypothetical protein -
HPY17_RS15705 415933..416043 + 111 WP_175246602.1 DUF3265 domain-containing protein -
HPY17_RS15710 416087..416446 + 360 WP_076025909.1 VOC family protein -
HPY17_RS15715 416615..417091 + 477 WP_175246603.1 DUF2059 domain-containing protein -
HPY17_RS15720 417291..418085 - 795 WP_175246424.1 NYN domain-containing protein -
HPY17_RS15725 418172..418327 + 156 WP_175246425.1 DUF3265 domain-containing protein -
HPY17_RS15730 418579..418692 + 114 Protein_437 DUF645 family protein -
HPY17_RS15735 418951..419232 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T158037 WP_000869999.1 NZ_CP053817:414106-414393 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T158037 NZ_CP069549:c2557444-2557130 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT158037 WP_000086649.1 NZ_CP053817:413828-414109 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT158037 NZ_CP069549:c2557680-2557447 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References