Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 388695..389193 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag HPY17_RS15455 Protein ID WP_000589156.1
Coordinates 388695..388961 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag HPY17_RS15460 Protein ID WP_000643598.1
Coordinates 388948..389193 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS15415 384093..384530 + 438 WP_172779930.1 NUDIX pyrophosphatase -
HPY17_RS15420 384599..384667 + 69 Protein_375 acetyltransferase -
HPY17_RS15425 384680..385618 + 939 WP_175247606.1 hypothetical protein -
HPY17_RS15430 385738..386026 + 289 Protein_377 DUF1289 domain-containing protein -
HPY17_RS15435 386281..386982 + 702 WP_001175917.1 hypothetical protein -
HPY17_RS15440 387615..388025 + 411 WP_025613414.1 cytidine deaminase -
HPY17_RS15445 387995..388132 + 138 WP_175246445.1 DUF3265 domain-containing protein -
HPY17_RS15450 388171..388518 + 348 WP_175247665.1 hypothetical protein -
HPY17_RS15455 388695..388961 + 267 WP_000589156.1 BrnT family toxin Toxin
HPY17_RS15460 388948..389193 + 246 WP_000643598.1 hypothetical protein Antitoxin
HPY17_RS15465 389337..390110 + 774 WP_175247666.1 aminoglycoside phosphotransferase family protein -
HPY17_RS15470 390405..390626 + 222 Protein_385 DUF645 family protein -
HPY17_RS15475 390996..391313 - 318 WP_175247667.1 CcdB family protein -
HPY17_RS15480 391313..391558 - 246 WP_001260801.1 type II toxin-antitoxin system CcdA family antitoxin -
HPY17_RS15485 391968..392285 - 318 WP_175247667.1 CcdB family protein -
HPY17_RS15490 392285..392530 - 246 WP_001260801.1 type II toxin-antitoxin system CcdA family antitoxin -
HPY17_RS15495 393110..393214 + 105 WP_175247668.1 DUF3265 domain-containing protein -
HPY17_RS15500 393201..393587 + 387 WP_001015087.1 MmcQ/YjbR family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T158036 WP_000589156.1 NZ_CP053817:388695-388961 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T158036 NZ_CP069549:c2326354-2325956 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT158036 WP_000643598.1 NZ_CP053817:388948-389193 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT158036 NZ_CP069549:c2326650-2326357 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References